长链非编码RNA LINC01857通过调控miR-2052/CENPQ轴降低乳腺癌细胞的转移和血管生成。
LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis.
作者信息
Qian Weiwei, Yang Linlin, Ni Yi, Yin Fei, Qin Lili, Yang Yang
机构信息
Department of Breast Surgery, Nantong Third People's Hospital, Nantong University, Nantong, Jiangsu Province, China.
Department of Oncology, Sheyang People's Hospital, Yancheng City, Jiangsu Province 224300, China.
出版信息
Open Med (Wars). 2022 Aug 10;17(1):1357-1367. doi: 10.1515/med-2022-0525. eCollection 2022.
Long non-coding RNAs have been confirmed closely related to the metastasis and angiogenesis of breast cancer (BC). LINC01857 can promote the growth and metastasis of BC cells. The present work focused on exploring the role of LINC01857 in BC metastasis and angiogenesis and investigating the possible mechanisms. The results showed that LINC01857 and CENPQ were highly expressed in BC tissues and cells, while miR-2052 was contrarily expressed. study showed that low expression of linc01857 could inhibit the migration ability and vascularization of BC cells, and mir-2052 inhibitor partially restored the effect of si-LINC01857 on the migration ability and vascularization of BC cells. Likewise, inhibition of CENPQ can partially rescue the effects of miR-2052 inhibitor on the migration ability and vascularization of BC cells. studies showed that down-regulation of LINC01857 notably suppressed tumor growth and angiogenesis in nude mice. The miR-2052 inhibitor partially restored the effects of si-LINC01857. CENPQ suppression partially rescued the effects of the miR-2052 inhibitor. To conclude, LINC01857/miR-2052/CENPQ is the potential novel target for BC treatment.
长链非编码RNA已被证实与乳腺癌（BC）的转移和血管生成密切相关。LINC01857可促进BC细胞的生长和转移。本研究聚焦于探索LINC01857在BC转移和血管生成中的作用，并研究其可能的机制。结果显示，LINC01857和CENPQ在BC组织和细胞中高表达，而miR-2052则呈相反表达。研究表明，LINC01857低表达可抑制BC细胞的迁移能力和血管生成，而miR-2052抑制剂可部分恢复si-LINC01857对BC细胞迁移能力和血管生成的影响。同样，抑制CENPQ可部分挽救miR-2052抑制剂对BC细胞迁移能力和血管生成的影响。研究表明，下调LINC01857可显著抑制裸鼠肿瘤生长和血管生成。miR-2052抑制剂可部分恢复si-LINC01857的作用。抑制CENPQ可部分挽救miR-2052抑制剂的作用。综上所述，LINC01857/miR-2052/CENPQ是BC治疗的潜在新靶点。
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