Dong Chen, Ma Xuehua, Huang Yi, Zhang Yujie, Gao Xiang
Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, China.
CAS Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China.
Front Bioeng Biotechnol. 2022 Aug 15;10:943399. doi: 10.3389/fbioe.2022.943399. eCollection 2022.
Developing an efficient antioxidant for anti-inflammatory therapy scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including OH, O , and ABTS•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also broadens the biomedical application of CDs in the treatment of inflammation.
开发一种用于抗炎治疗的高效抗氧化剂以清除活性氧（ROS），由于传统抗氧化剂活性和稳定性不足，仍然是一个巨大的挑战。在此，我们探索并简单合成了一种具有生物相容性的碳点（CDs）纳米酶，其对ROS具有优异的清除活性，可用于抗炎治疗。正如预期的那样，CDs纳米酶能有效清除多种自由基，包括OH、O 和ABTS•。得益于对ROS的多种酶活性，CDs纳米酶可降低促炎细胞因子水平，从而产生良好的抗炎效果。综上所述，本研究不仅为生物活性抗氧化剂的设计提供了思路，还拓宽了CDs在炎症治疗中的生物医学应用。
