Gao Lei, Li Jing, Song Tianhang
The Second Hospital of Tianjin Medical University, Tianjin, China.
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Front Chem. 2022 Aug 15;10:973666. doi: 10.3389/fchem.2022.973666. eCollection 2022.
Cancer has emerged as one of the most severe diseases in modern times, various therapies have advanced remarkably in recent decades. Unlike the direct therapeutic targeting tumor cells, immunotherapy is a promising strategy that stimulate the immune system. In cancer immunotherapy, polymeric-based nanoparticles can serve as deliver systems for antigens and immunostimulatory molecules, and they have attracted increasing attention and revolutionized cancer therapy. Poly (lactic-co-glycolic acid) (PLGA) is the most frequently used clinically approved biodegradable polymer and has a broad scope of modification of its inherent properties. Recent advances in PLGA based drug delivery systems in cancer immunotherapy have been described in this mini review, with special emphasis on cancer vaccines and tumor microenvironment modulation.
癌症已成为现代最严重的疾病之一，近几十年来各种治疗方法有了显著进展。与直接靶向肿瘤细胞的治疗方法不同，免疫疗法是一种刺激免疫系统的有前景的策略。在癌症免疫疗法中，基于聚合物的纳米颗粒可作为抗原和免疫刺激分子的递送系统，它们已引起越来越多的关注并彻底改变了癌症治疗。聚乳酸-羟基乙酸共聚物（PLGA）是临床上最常用的经批准的可生物降解聚合物，并且对其固有特性具有广泛的修饰范围。本综述介绍了基于PLGA的药物递送系统在癌症免疫疗法中的最新进展，特别强调了癌症疫苗和肿瘤微环境调节。
