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通过纵向和横向评估得出的妊娠和产后女性的脂质组学特征：由超高效液相色谱-四极杆飞行时间-电喷雾电离质谱法确定的潜在生物标志物

Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI-MS.

作者信息

Traila Alexandra, Craina Marius, Socaciu Carmen, Socaciu Andreea Iulia, Nitusca Diana, Marian Catalin

机构信息

Doctoral School, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.

Obstetrics and Gynecology Clinic, Emergency Municipal Clinical Hospital, 300172 Timisoara, Romania.

出版信息

Metabolites. 2025 Jan 8;15(1):27. doi: 10.3390/metabo15010027.

DOI:10.3390/metabo15010027
PMID:39852370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11768031/
Abstract

BACKGROUND

Pregnancy induces significant physiological and metabolic changes in the mother to support fetal growth and prepare for childbirth. These adaptations impact various systems, including immune tolerance, metabolism, and endocrine function. While metabolomics has been utilized to study pregnancy-related metabolic changes, comprehensive comparisons between pregnant and non-pregnant states, particularly using ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS), remain limited.

METHODS

This study aimed to explore the dynamic, longitudinal metabolic shifts during pregnancy by profiling plasma samples from 65 pregnant women across three time points (6-14 weeks, 14-22 weeks, and >24 weeks) and 42 postpartum women. Lipidomics was prioritized, and a solvent mixture was employed to enhance lipid extraction, using UHPLC-QTOF-ESI-MS.

RESULTS

A total of 290 metabolites were identified and analyzed. Our results revealed significant metabolic differences between pregnant and postpartum women, with lipid molecules such as estrogen derivatives, fatty acids, and ceramides showing strong potential as biomarkers. Further biomarker analysis highlighted distinct metabolic signatures between early and late pregnancy stages, particularly in lipid metabolism (with AUC values > 0.8).

CONCLUSIONS

These findings contribute to a deeper understanding of pregnancy-related metabolic changes and may offer insights into maternal and neonatal health outcomes.

摘要

背景

怀孕会在母亲体内引发显著的生理和代谢变化，以支持胎儿生长并为分娩做准备。这些适应性变化会影响包括免疫耐受、代谢和内分泌功能在内的各种系统。虽然代谢组学已被用于研究与怀孕相关的代谢变化，但怀孕与未怀孕状态之间的全面比较，尤其是使用超高效液相色谱与质谱联用（UHPLC-MS）的比较，仍然有限。

方法

本研究旨在通过分析65名孕妇在三个时间点（6 - 14周、14 - 22周和>24周）以及42名产后妇女的血浆样本，探索怀孕期间动态的纵向代谢变化。优先进行脂质组学研究，并使用UHPLC-QTOF-ESI-MS，采用一种溶剂混合物来增强脂质提取。

结果

共鉴定并分析了290种代谢物。我们的结果显示，孕妇和产后妇女之间存在显著的代谢差异，雌激素衍生物、脂肪酸和神经酰胺等脂质分子显示出作为生物标志物的强大潜力。进一步的生物标志物分析突出了怀孕早期和晚期阶段之间不同的代谢特征，特别是在脂质代谢方面（曲线下面积值>0.8）。

结论

这些发现有助于更深入地理解与怀孕相关的代谢变化，并可能为母婴健康结果提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/edaaa93cb768/metabolites-15-00027-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/81d147516a8f/metabolites-15-00027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/cb9364a79fcc/metabolites-15-00027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/c066755f2637/metabolites-15-00027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/c45d75dd6be3/metabolites-15-00027-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/2d3544b51fa0/metabolites-15-00027-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/edaaa93cb768/metabolites-15-00027-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/81d147516a8f/metabolites-15-00027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/cb9364a79fcc/metabolites-15-00027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/c066755f2637/metabolites-15-00027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/c45d75dd6be3/metabolites-15-00027-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/2d3544b51fa0/metabolites-15-00027-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cad/11768031/edaaa93cb768/metabolites-15-00027-g006.jpg

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