Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.
Department of Veterinary Surgery and Theriogenology, School of Veterinary Medicine, Mongolian University of Life Science, Ulaanbaatar, Mongolia.
J Vet Med Sci. 2022 Oct 7;84(10):1437-1441. doi: 10.1292/jvms.22-0113. Epub 2022 Aug 30.
The aim of this study was to investigate the anti-hepcidin effect of pentosan polysulfate (PPS) in Mongolian horses. Twenty-six healthy horses were randomly allocated in to two-groups; one group was treated with a PPS once a week for 4-weeks while another group keeping as placebo. Blood samples at day 0 (D0), before race (BR; day 28) and after race (AR; day 28) were analyzed for serum biochemistry, hepcidin and iron concentrations. Significant reduction of hepcidin was observed at AR in PPS group when compared with BR placebo (P<0.05) and AR placebo (P<0.01). Mean hepcidin concentration difference of D0-BR and BR-AR in PPS was greater than the placebo whereas the iron concentration difference is reduced compared to placebo. Results indicate a novel therapeutic application of PPS as an anti-hepcidin compound to control hepcidin in horses while emphasizing further molecular studies.
本研究旨在探讨戊聚糖多硫酸酯（PPS）对蒙古马抗hepcidin 的作用。26 匹健康马被随机分为两组；一组每周用 PPS 治疗一次，共 4 周，另一组作为安慰剂。在第 0 天（D0）、比赛前（BR；第 28 天）和比赛后（AR；第 28 天）采集血样，分析血清生化、hepcidin 和铁浓度。与 BR 安慰剂（P<0.05）和 AR 安慰剂（P<0.01）相比，PPS 组在 AR 时 hepcidin 显著降低。与安慰剂相比，PPS 组的 D0-BR 和 BR-AR 平均 hepcidin 浓度差异更大，而铁浓度差异则低于安慰剂。结果表明，PPS 作为一种抗 hepcidin 化合物具有治疗马 hepcidin 的新应用前景，同时强调了进一步的分子研究。
