Ma Xiaoya, Patterson Kaitlyn J, Gieschen Kayla M, Bodary Peter F
Dept. of Movement Science, University of Michigan, Ann Arbor, MI.
Int J Sport Nutr Exerc Metab. 2013 Oct;23(5):513-21. doi: 10.1123/ijsnem.23.5.513. Epub 2013 Apr 9.
The prevalence of iron deficiency tends to be higher in athletic populations, especially among endurance-trained females. Recent studies have provided evidence that the iron-regulating hormone hepcidin is transiently increased with acute exercise and suggest that this may contribute to iron deficiency anemia in athletes. The purpose of this study was to determine whether resting serum hepcidin is significantly elevated in highly trained female distance runners compared with a low exercise control group. Due to the importance of the monocyte in the process of iron recycling, monocyte expression of hepcidin was also measured. A single fasted blood sample was collected midseason from twenty female distance runners averaging 81.9 ± 14.2 km of running per week. Ten age-, gender-, and BMI-matched low-exercise control subjects provided samples during the same period using identical collection procedures. There was no difference between the runners (RUN) and control subjects (CON) for serum hepcidin levels (p = .159). In addition, monocyte hepcidin gene expression was not different between the two groups (p = .635). Furthermore, no relationship between weekly training volume and serum hepcidin concentration was evident among the trained runners. The results suggest that hepcidin is not chronically elevated with sustained training in competitive collegiate runners. This is an important finding because the current clinical conditions that link hepcidin to anemia include a sustained elevation in serum hepcidin. Nevertheless, additional studies are needed to determine the clinical relevance of the well-documented, transient rise in hepcidin that follows acute sessions of exercise.
缺铁在运动员群体中更为普遍，尤其是在耐力训练的女性中。最近的研究表明，铁调节激素铁调素在急性运动后会短暂升高，并提示这可能导致运动员缺铁性贫血。本研究的目的是确定与低运动量对照组相比，经过高强度训练的女子长跑运动员静息血清铁调素是否显著升高。由于单核细胞在铁循环过程中的重要性，还测量了单核细胞中铁调素的表达。在赛季中期，从20名女子长跑运动员中采集了一份空腹血样，这些运动员平均每周跑步81.9±14.2公里。10名年龄、性别和BMI匹配的低运动量对照受试者在同一时期使用相同的采集程序提供了样本。跑步运动员（RUN）和对照受试者（CON）的血清铁调素水平没有差异（p = 0.159）。此外，两组之间的单核细胞铁调素基因表达也没有差异（p = 0.635）。此外，在训练有素的跑步运动员中，每周训练量与血清铁调素浓度之间没有明显关系。结果表明，在有竞争力的大学跑步运动员中，铁调素不会因持续训练而长期升高。这是一个重要的发现，因为目前将铁调素与贫血联系起来的临床情况包括血清铁调素持续升高。然而，还需要进一步的研究来确定运动后铁调素短暂升高这一已被充分记录的现象的临床相关性。
