Allgulander C, Ljungberg L, Fisher L D
Acta Psychiatr Scand. 1987 May;75(5):521-31. doi: 10.1111/j.1600-0447.1987.tb02828.x.
The prognosis of 221 patients first admitted in 1941-1954 for dependence on sedative-hypnotic drugs was determined in a record-linkage and interview study concluded in 1984. Different outcomes were related to admission characteristics by means of the Cox proportional hazards regression model. An excess of unnatural deaths was noted; suicides in 11% of the men and 23% of the women. Of those with primary sedative-hypnotic dependence, 46% continued to abuse drugs till death or follow-up, and of those with a primary or concomitant alcohol abuse 72%. An unfavorable outcome was significantly related to primary psychiatric symptoms before the first admission, concomitant alcohol abuse, familial drug and alcohol abuse and health care occupation.
在一项于1984年完成的记录链接和访谈研究中，确定了1941年至1954年首次因依赖镇静催眠药物入院的221名患者的预后。通过Cox比例风险回归模型，将不同的结局与入院特征相关联。发现非自然死亡人数过多；男性自杀率为11%，女性为23%。在原发性镇静催眠药物依赖者中，46%的人直到死亡或随访时仍继续滥用药物，而在原发性或合并酒精滥用者中，这一比例为72%。不良结局与首次入院前的原发性精神症状、合并酒精滥用、家族性药物和酒精滥用以及医疗保健职业显著相关。
