Allgulander C, Allebeck P, Przybeck T R, Rice J P
Department of Psychiatry, Huddinge University Hospital, Stockholm, Sweden.
Eur Arch Psychiatry Clin Neurosci. 1992;241(5):323-6. doi: 10.1007/BF02195984.
The risk of suicide associated with different psychiatric diagnoses was estimated in 80,970 inpatients in Stockholm County (population 1.6 million). All patients discharged with at least one psychiatric diagnosis between 1973 and 1986 were followed by linkage with the cause-of-death registry through 1987. There were 1,115 definite suicides and 467 undetermined suicides among these during the 15-year follow-up. When 12 diagnostic categories were entered in a proportional hazards model, the highest relative risk (RR) of definite suicide, controlling for sex and age, was noted for affective disorders (RR 2.82), followed by unspecified psychoses (RR 2.69), paranoid psychoses (RR 2.60), addiction to prescription drugs (RR 2.38), neuroses and reactive psychoses (RR 1.96), and schizophrenia (RR 1.64). Alcoholism, personality disorders, organic psychoses, and street drug addiction did not have significantly increased risks of suicide. Male sex increased the risk for definite suicide by 1.56, while the risk was somewhat higher among the young. Having more than one diagnosis increased the relative risk by 1.42. When undetermined suicides were included in the analysis, to alcoholism and street drug abuse were attributed significantly increased risks of suicide, probably owing to the greater difficulty of verifying such cases. We conclude that several psychiatric disorders were conductive to suicide, but that the risk did not vary much with the type of diagnosis. Further studies of confounders are needed, such as the reasons for being admitted to inpatient care, and the impact of somatic and psychiatric comorbidity.
在斯德哥尔摩县(人口160万)的80970名住院患者中,评估了与不同精神科诊断相关的自杀风险。1973年至1986年间所有至少有一种精神科诊断出院的患者,通过与死因登记处的关联一直随访至1987年。在这15年的随访期间,这些患者中有1115例明确自杀和467例自杀情况不明。当将12个诊断类别纳入比例风险模型时,在控制性别和年龄后,发现情感障碍的明确自杀相对风险(RR)最高(RR 2.82),其次是未特定的精神病(RR 2.69)、偏执性精神病(RR 2.60)、处方药成瘾(RR 2.38)、神经症和反应性精神病(RR 1.96)以及精神分裂症(RR 1.64)。酒精中毒、人格障碍、器质性精神病和街头药物成瘾的自杀风险没有显著增加。男性使明确自杀的风险增加1.56倍,而年轻人中的风险略高。有不止一种诊断会使相对风险增加1.42倍。当将自杀情况不明的案例纳入分析时,酒精中毒和街头药物滥用的自杀风险显著增加,这可能是由于核实此类案例的难度更大。我们得出结论,几种精神障碍会导致自杀,但风险并未因诊断类型而有太大差异。需要进一步研究混杂因素,例如住院治疗的原因,以及躯体和精神共病的影响。