Department of Oral Pathology, Wroclaw Medical University, Poland.
Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Poland.
Adv Clin Exp Med. 2022 Dec;31(12):1327-1334. doi: 10.17219/acem/152429.
Oral lichen planus (OLP) and oral lichenoid lesions (OLL) comprise a group of oral mucosal disorders that have similar clinical and histological features.
To compare the levels of investigated biomarkers in biopsied OLP and OLL, and to determine the pattern of biomarkers, which could be useful for the biological characterization of these 2 disorders.
A total of 56 biopsy specimens in 2 groups were analyzed in this study. One group consisted of 25 idiopathic OLP lesions, and the other included 31 OLL from patients treated with antihypertensive and cardiac medications. The expression of protein p53, topoisomerase I (topo I), heat shock protein 90 (HSP90), and E-cadherin was analyzed using immunohistochemistry.
The p53 protein expression showed a trend to a positive correlation with topo I expression in the total sample (p = 0.067, R = 0.25). The p53 protein and HSP90 expression was higher in the OLL group compared to the OLP group, but the difference was not statistically significant. No association was found between topo I and E-cadherin expression for either the OLP or OLL group.
The findings of this study suggest that the slightly higher protein p53 and HSP90 expression in the OLL group might be caused by the medications used. The slight association between p53 and topo I expression indicates that the cooperation between these proteins might be essential for the growth of OLP/OLL in general. We conclude that the overexpression of p53 protein and high expression of topo I found in both types of lesions might induce their biologically aggressive behavior.
口腔扁平苔藓（OLP）和口腔类扁平苔藓病变（OLL）是一组具有相似临床和组织学特征的口腔黏膜疾病。
比较活检 OLP 和 OLL 中研究生物标志物的水平，并确定这些生物标志物的模式，这可能有助于这两种疾病的生物学特征分析。
本研究分析了两组共 56 个活检标本。一组包括 25 个特发性 OLP 病变，另一组包括 31 个接受抗高血压和心脏药物治疗的 OLL 患者。使用免疫组织化学法分析蛋白质 p53、拓扑异构酶 I（topo I）、热休克蛋白 90（HSP90）和 E-钙黏蛋白的表达。
总样本中 p53 蛋白表达与 topo I 表达呈正相关趋势（p = 0.067，R = 0.25）。与 OLP 组相比，OLL 组的 p53 蛋白和 HSP90 表达更高，但差异无统计学意义。OLP 或 OLL 组中，topo I 和 E-钙黏蛋白的表达之间均无相关性。
本研究结果表明，OLL 组中 p53 蛋白和 HSP90 表达略高可能是由于使用了药物。p53 与 topo I 表达之间的轻微相关性表明，这些蛋白之间的合作可能对 OLP/OLL 的生长至关重要。我们得出结论，两种病变中 p53 蛋白的过度表达和 topo I 的高表达可能导致其生物学侵袭性行为。
