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p53 蛋白上调在口腔扁平苔藓中的意义：系统评价和荟萃分析。

Implications of p53 protein upregulation in oral lichen planus: a systematic review and meta-analysis.

机构信息

Oral Medicine, Department of Stomatology School of Dentistry, University of Granada Paseo de Cartuja s/n, 18071, Granada, Spain

出版信息

Med Oral Patol Oral Cir Bucal. 2024 Nov 1;29(6):e832-e842. doi: 10.4317/medoral.26808.

DOI:10.4317/medoral.26808
PMID:39396145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11584960/
Abstract

BACKGROUND

This systematic review and meta-analysis qualitatively and quantitatively analyzes the current evidence on the implications of p53 upregulation in oral lichen planus (OLP) assessed by immunohistochemical techniques, in order to identify molecular mechanisms involved in the behavior of OLP as an oral potentially malignant disorder.

MATERIAL AND METHODS

We searched MEDLINE/PubMed, Embase, Web of Science and Scopus for studies published before February-2024. We critically assessed the methodological quality of primary-level studies and performed meta-analyses.

RESULTS

Twenty-four individual studies met the inclusion criteria, comprising 721 OLP samples, in which the expression of p53 was analyzed through immunohistochemistry. Most OLP displayed p53 protein upregulation (pooled proportion [PP]= 66.76%, 95%CI=54.84-77.76). Regarding the magnitude of association analysis, oral squamous cell carcinoma (OSCC) cases showed a significantly higher frequency according to p53 expression in comparison to OLP (OR=2.79, 95%CI=1.84-4.24; p<0.001); while, OLP exhibited a significantly higher frequency for p53 expression in comparison to healthy controls (OR=5.70, 95%CI=2.90-11.19; p<0.001).

CONCLUSIONS

In conclusion, the present study demonstrates the frequent p53 protein upregulation in patients with OLP, which is probably indicating an antitumor response in an epithelium whose cells are under cellular stress and at risk of cancer.

摘要

背景

本系统评价和荟萃分析通过免疫组织化学技术定性和定量分析了口腔扁平苔藓（OLP）中 p53 上调的当前证据所暗示的意义，以确定涉及 OLP 作为口腔潜在恶性疾病行为的分子机制。

材料和方法

我们在 MEDLINE/PubMed、Embase、Web of Science 和 Scopus 中搜索了截至 2024 年 2 月之前发表的研究。我们对初级研究的方法学质量进行了批判性评估，并进行了荟萃分析。

结果

24 项单独的研究符合纳入标准，包括 721 例 OLP 样本，其中通过免疫组织化学分析了 p53 的表达。大多数 OLP 显示出 p53 蛋白上调（合并比例 [PP]=66.76%，95%CI=54.84-77.76）。关于关联分析的幅度，口腔鳞状细胞癌（OSCC）病例根据 p53 表达的频率明显高于 OLP（OR=2.79，95%CI=1.84-4.24；p<0.001）；而 OLP 中 p53 表达的频率明显高于健康对照组（OR=5.70，95%CI=2.90-11.19；p<0.001）。

结论

总之，本研究表明 OLP 患者中 p53 蛋白频繁上调，这可能表明在细胞处于细胞应激和癌症风险下的上皮组织中存在抗肿瘤反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/ee8a07844263/medoral-29-e832-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/72966076a974/medoral-29-e832-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/5d780bc1f7b6/medoral-29-e832-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/ee8a07844263/medoral-29-e832-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/72966076a974/medoral-29-e832-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/5d780bc1f7b6/medoral-29-e832-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cdf/11584960/ee8a07844263/medoral-29-e832-g003.jpg

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