Smith Leon, Zeman Brian
Department of Rehabilitation Medicine, Royal North Shore Hospital, St Leonard's, NSW, Australia.
Case Rep Neurol Med. 2022 Aug 23;2022:4933172. doi: 10.1155/2022/4933172. eCollection 2022.
Although COVID-19 was initially described predominantly as a respiratory infection, subsequent reports noted that it can produce generalised inflammation with effects on multiple organ systems. As a result, it is possible for patients with COVID-19, including those with severe disease, to present initially with nonrespiratory signs and symptoms. Neurological manifestations, including ischaemic stroke, may be the first presenting issue and can result from carotid thrombosis. Similarly, the risk of both arterial and venous thrombosis is increased in COVID-19, which may result from hypercoagulability associated with systemic inflammation.
尽管最初主要将 COVID-19 描述为一种呼吸道感染,但随后的报告指出,它可引发全身性炎症,对多个器官系统产生影响。因此,COVID-19 患者,包括重症患者,最初可能表现出非呼吸道症状和体征。神经学表现,包括缺血性中风,可能是首发问题,且可能由颈动脉血栓形成导致。同样,COVID-19 患者发生动脉和静脉血栓形成的风险均会增加,这可能是由与全身炎症相关的高凝状态引起的。