Kim Madeleine, George Andrew, Ganti Latha, Huang Derrick, Carman Matthew
The Baylor School, Chatanooga, Tennessee, United States.
Department of Biology and Medicine, Brown University, Providence, Rhode Island, United States.
TH Open. 2022 Feb 3;6(2):e96-e98. doi: 10.1055/a-1760-0445. eCollection 2022 Apr.
The novel coronavirus disease 2019 (COVID-19) infection has widespread impact on multiple organ systems, including damage to endothelial cells. Various studies have found evidence for direct mechanisms by which interaction between severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and endothelial cells lead to extensive damage to the latter, and indirect mechanisms, such as excessively elevated cytokines, can also result in the same outcome. Damage to the endothelium results in release of thrombotic factors and inhibition of fibrinolysis. This confers a significant hypercoagulability burden on patients infected or recovering from COVID-19 infection. In this case report, the authors report the case of a gentleman presenting with extensive deep vein thrombosis and pulmonary embolism, in the context of recent COVID-19 infection. The postulated mechanisms and management are discussed.
2019年新型冠状病毒病（COVID-19）感染对多个器官系统产生广泛影响，包括对内皮细胞的损害。各种研究已发现证据表明，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与内皮细胞之间的相互作用导致后者广泛损伤的直接机制，而间接机制，如细胞因子过度升高，也可导致相同结果。内皮损伤导致血栓形成因子释放和纤维蛋白溶解受抑制。这给感染COVID-19或从COVID-19感染中康复的患者带来了显著的高凝负担。在本病例报告中，作者报告了一名近期感染COVID-19的男性患者出现广泛深静脉血栓形成和肺栓塞的病例。文中讨论了推测的机制和治疗方法。
