Wang Jun-Hong, Gao Zhen-Hua, Qian Hong-Liang, Li Jin-Shun, Ji Hao-Min, Da Ming-Xu
The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Department of Hepatobiliary Surgery, The First People's Hospital of Baiyin, Baiyin 730900, Gansu Province, China.
World J Clin Cases. 2022 Jul 16;10(20):7082-7089. doi: 10.12998/wjcc.v10.i20.7082.
Pyogenic liver abscesses are insidious in the early stage. Some cases progress rapidly, and the patient's condition can worsen and even become life-threatening if timely treatment is not provided. Surgery and prolonged antibiotic treatment are often required if the abscess is large and liquefied and becomes separated within the lumen.
We report a case of bacterial liver abscess with a poor outcome following pharmacological treatment, review the literature related to the use of platelet-rich plasma (PRP) in the treatment of hepatic impairment and partial hepatectomy in animals, and discuss the prognostic features of surgical incision and drainage combined with PRP in the treatment of bacterial liver abscesses. This is the first case describing the use of PRP in the treatment of a bacterial liver abscess in humans, providing new ideas for the treatment of this condition.
This case highlights the importance of surgical treatment for bacterial liver abscesses that are well liquefied and poorly managed medically. PRP may produce antimicrobial effects and promote the regeneration and repair of liver tissue.
化脓性肝脓肿在早期较为隐匿。部分病例进展迅速,如果不及时治疗,患者病情会恶化甚至危及生命。如果脓肿较大且已液化并在腔内形成分隔,则通常需要手术及长期抗生素治疗。
我们报告1例经药物治疗效果不佳的细菌性肝脓肿病例,回顾动物中使用富血小板血浆(PRP)治疗肝损伤及部分肝切除术的相关文献,并探讨手术切开引流联合PRP治疗细菌性肝脓肿的预后特征。这是首例描述PRP用于治疗人类细菌性肝脓肿的病例,为该病的治疗提供了新思路。
本病例突出了手术治疗对于液化良好但药物治疗效果不佳的细菌性肝脓肿的重要性。PRP可能具有抗菌作用并促进肝组织的再生和修复。