Department of Urology, Chongqing General Hospital, No. 118, Xingguang Avenue, Liangjiang New Area, Chongqing 401147, China.
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China.
Biomed Res Int. 2022 Aug 23;2022:9430509. doi: 10.1155/2022/9430509. eCollection 2022.
Tripartite motif (TRIM) protein family proteins contain more than 80 members in humans, and most of these proteins exhibit E3 ubiquitin ligase activity mediated through a RING finger domain. Their biological functions are very complex, and they perform diverse functions in cell evolution processes, such as intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy, and carcinogenesis. Tripartite motif-containing protein 2 (TRIM2), a member of the TRIM superfamily, is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3. TRIM2 functions as an E3 ubiquitin ligase. Current studies have shown that TRIM2 can play roles in neuroprotection, neuronal rapid ischemic tolerance, antiviral responses, neurological diseases, etc. Moreover, based on some studies in tumors, TRIM2 regulates tumor proliferation, migration, invasion, apoptosis, and drug resistance through different mechanisms and plays a critical role in tumor occurrence and development. This review is aimed at providing a systematic and comprehensive summary of research on TRIM2 and at exploring the potential role of TRIM2 as a biomarker and therapeutic target in many kinds of human diseases.
三基序蛋白（TRIM）家族蛋白在人类中包含 80 多个成员，其中大多数蛋白通过一个 RING 指结构域表现出 E3 泛素连接酶活性。它们的生物学功能非常复杂，在细胞进化过程中发挥着多种功能，如细胞内信号转导、发育、细胞凋亡、蛋白质质量控制、先天免疫、自噬和癌症发生。三基序蛋白 2（TRIM2）是 TRIM 超家族的一个成员，是一种 81kDa 的多结构域蛋白，也称为 CMT2R 或 RNF86，位于 4q31.3。TRIM2 作为 E3 泛素连接酶发挥作用。目前的研究表明，TRIM2 可以在神经保护、神经元快速缺血耐受、抗病毒反应、神经疾病等方面发挥作用。此外，基于一些肿瘤的研究，TRIM2 通过不同的机制调节肿瘤的增殖、迁移、侵袭、凋亡和耐药性，在肿瘤的发生和发展中起着关键作用。本文旨在对 TRIM2 的研究进行系统全面的总结，并探讨 TRIM2 作为多种人类疾病的生物标志物和治疗靶点的潜在作用。
