Hu Zhengyi, Mao Leifang, Wang Ling
Ethics Office, Henan Provincial Chest Hospital, Zhengzhou 450003, Henan, China.
Department of Rehabilitation, Henan Provincial Chest Hospital, Zhengzhou 450003, Henan, China.
Evid Based Complement Alternat Med. 2022 Aug 23;2022:4118976. doi: 10.1155/2022/4118976. eCollection 2022.
To investigate the levels of serum insulin like growth factor-1 (IGF-1), homocysteine (HCY), and plasma brain natriuretic peptide (BNP) in patients with chronic congestive heart failure (CCHF) and their relationship with cardiac function and short-term prognosis.
A total of 95 patients with CCHF admitted to our hospital from October 2017 to December 2018 were selected as the observation group. Patients conform to grade II∼IV of the New York Heart Association (NYHA) heart function class. At the same time, the people with normal physical examination results were selected as a control group. Serum IGF-1, HCY, and plasma BNP levels were detected in the two groups, and left ventricular end-diastolic diameter (LVDd) and left ventricular ejection fraction (LVEF) were detected in the observation group. According to the follow-up results, the observation group was divided into the subgroup with good prognosis and the subgroup with poor prognosis. The relationship between the levels of serum IGF-1, HCY, and plasma BNP among cardiac function and short-term prognosis were analyzed.
The serum IGF-1 level of the observation group was lower than that of the control group, and the serum HCY and plasma BNP levels were higher than those of the control group ( < 0.05). Serum IGF-1 level in grade III of NYHA was lower than that in grade II, and serum HCY and plasma BNP levels were higher than those in grade II. Serum IGF-1 level in grade IV was lower than that in grade II and grade III, and serum HCY and plasma BNP levels were higher than those in grade II and grade III ( < 0.05). Serum IGF-1 level was negatively correlated with LVDd and positively correlated with LVEF. Serum HCY and plasma BNP levels were positively correlated with LVDd and negatively correlated with LVEF ( < 0.05). There were 42 patients with poor prognoses (44.21%). Serum IGF-1 levels of patients with poor prognosis were lower than those with good prognosis, and serum HCY and plasma BNP levels were higher than those with good prognosis ( < 0.05).
The serum IGF-1 level in patients with CCHF decreased, and serum HCY and plasma BNP levels increased. Serum IGF-1, HCY, and plasma BNP were correlated with cardiac function and have some clinical value for short-term prognosis.
探讨慢性充血性心力衰竭（CCHF）患者血清胰岛素样生长因子-1（IGF-1）、同型半胱氨酸（HCY）及血浆脑钠肽（BNP）水平及其与心功能和短期预后的关系。
选取2017年10月至2018年12月我院收治的95例CCHF患者作为观察组。患者符合纽约心脏协会（NYHA）心功能分级Ⅱ～Ⅳ级。同时，选取体检结果正常者作为对照组。检测两组患者血清IGF-1、HCY及血浆BNP水平，观察组检测左心室舒张末期内径（LVDd）和左心室射血分数（LVEF）。根据随访结果，将观察组分为预后良好亚组和预后不良亚组。分析血清IGF-1、HCY及血浆BNP水平与心功能及短期预后的关系。
观察组血清IGF-1水平低于对照组，血清HCY及血浆BNP水平高于对照组（P<0.05）。NYHAⅢ级患者血清IGF-1水平低于Ⅱ级，血清HCY及血浆BNP水平高于Ⅱ级。NYHAⅣ级患者血清IGF-1水平低于Ⅱ级和Ⅲ级，血清HCY及血浆BNP水平高于Ⅱ级和Ⅲ级（P<0.05）。血清IGF-1水平与LVDd呈负相关，与LVEF呈正相关。血清HCY及血浆BNP水平与LVDd呈正相关，与LVEF呈负相关（P<0.05）。预后不良患者42例（44.21%）。预后不良患者血清IGF-1水平低于预后良好患者，血清HCY及血浆BNP水平高于预后良好患者（P<0.05）。
CCHF患者血清IGF-1水平降低，血清HCY及血浆BNP水平升高。血清IGF-1、HCY及血浆BNP与心功能相关，对短期预后有一定临床价值。
