Khandibharad Shweta, Nimsarkar Prajakta, Singh Shailza
National Centre for Cell Science, NCCS Complex, Ganeshkhind, SP Pune University Campus, Pune, 411007, India.
Curr Res Immunol. 2022 Aug 23;3:186-198. doi: 10.1016/j.crimmu.2022.08.007. eCollection 2022.
Cytokines are influential molecules which can direct cells behavior. In this review, cytokines are referred as messengers, immune cells which respond to cytokine stimulus are referred as receivers and the immune cells which gets modulated due to their plasticity induced by infectious pathogen leishmania, are referred as followers. The advantage of plasticity of cells is taken by the parasite to switch them from parasite eliminating form to parasite survival favoring form through a process called as reciprocity which is undergone by cytokines, wherein pro-inflammatory to anti-inflammatory switch occur rendering immune cell population to switch their phenotype. Detailed study of this switch can help in identification of important targets which can help in restoring the phenotype to parasite eliminating form and this can be done through synthetic circuit, finding its wider applicability in therapeutics.
细胞因子是能够指导细胞行为的有影响力的分子。在本综述中，细胞因子被称为信使，对细胞因子刺激作出反应的免疫细胞被称为受体，而由于感染病原体利什曼原虫诱导的可塑性而受到调节的免疫细胞被称为跟随者。寄生虫利用细胞可塑性的优势，通过细胞因子经历的一种称为互易性的过程，将它们从寄生虫清除形式转变为有利于寄生虫生存的形式，其中发生促炎到抗炎的转变，使免疫细胞群体改变其表型。对这种转变的详细研究有助于确定重要靶点，这些靶点有助于将表型恢复到寄生虫清除形式，这可以通过合成回路来实现，从而在治疗中找到更广泛的应用。
