de Mello Anna Julie, Moretti Morgana, Rodrigues Ana Lúcia S
Department of Biochemistry, Universidade Federal de Santa Catarina, Florianópolis 88040-200, Brazil.
World J Psychiatry. 2022 Jul 19;12(7):874-883. doi: 10.5498/wjp.v12.i7.874.
The coronavirus disease 2019 (COVID-19) pandemic has been linked to an increased prevalence of mental health disorders, particularly anxiety and depression. Moreover, the COVID-19 pandemic has caused stress in people worldwide due to several factors, including fear of infection; social isolation; difficulty in adapting to new routines; lack of coping methods; high exposure to social media, misinformation, and fake reports; economic impact of the measures implemented to slow the contagion and concerns regarding the disease pathogenesis. COVID-19 patients have elevated levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, and other inflammation-related factors. Furthermore, invasion of the central nervous system by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may potentially contribute to neuroinflammatory alterations in infected individuals. Neuroinflammation, a consequence of psychological stress due to the COVID-19 pandemic, may also play a role in the development of anxiety and depressive symptoms in the general population. Considering that neuroinflammation plays a significant role in the pathophysiology of depression and anxiety, this study investigated the effects of SARS-CoV-2 on mental health and focused on the impact of the COVID-19 pandemic on the neuroinflammatory pathways.
2019年冠状病毒病（COVID-19）大流行与心理健康障碍患病率增加有关，尤其是焦虑和抑郁。此外，COVID-19大流行由于多种因素给全球各地的人们带来了压力，这些因素包括对感染的恐惧；社交隔离；难以适应新的日常安排；缺乏应对方法；大量接触社交媒体、错误信息和虚假报道；为减缓传播而实施的措施所带来的经济影响以及对疾病发病机制的担忧。COVID-19患者的促炎细胞因子水平升高，如白细胞介素（IL）-1β、IL-6和肿瘤坏死因子-α，以及其他与炎症相关的因子。此外，新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）侵入中枢神经系统可能会导致受感染个体出现神经炎症改变。神经炎症是COVID-19大流行导致心理压力的结果，也可能在普通人群焦虑和抑郁症状的发展中起作用。鉴于神经炎症在抑郁症和焦虑症的病理生理学中起重要作用，本研究调查了SARS-CoV-2对心理健康的影响，并重点关注COVID-19大流行对神经炎症途径的影响。
