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在患有严重急性呼吸综合征和癫痫发作的患者中枢神经系统中检测严重急性呼吸综合征冠状病毒2

Detection of SARS-coronavirus-2 in the central nervous system of patients with severe acute respiratory syndrome and seizures.

作者信息

Rezaeitalab Fariborz, Jamehdar Saeid Amel, Sepehrinezhad Ali, Rashidnezhad Azra, Moradi Fereydoun, Sadat Esmaeli Fard Fateme, Hasanzadeh Sepideh, Etezad Razavi Mohammad, Gorji Ali, Sahab Negah Sajad

机构信息

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

J Neurovirol. 2021 Apr;27(2):348-353. doi: 10.1007/s13365-020-00938-w. Epub 2021 Mar 1.

DOI:10.1007/s13365-020-00938-w
PMID:33650073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7920401/
Abstract

This study was designed to evaluate whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can directly target the central nervous system (CNS). We present four patients suffering from the loss of consciousness and seizure during the clinical course of COVID-19 infection. In addition to positive nasopharyngeal swab tests, SARS-CoV-2 has been detected in their cerebrospinal fluid. This report indicates the neuroinvasive potential of SARS-CoV-2, suggesting the ability of this virus to spread from the respiratory tract to the CNS.

摘要

本研究旨在评估严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是否能直接靶向中枢神经系统（CNS）。我们报告了4例在新型冠状病毒肺炎（COVID-19）感染临床过程中出现意识丧失和癫痫发作的患者。除鼻咽拭子检测呈阳性外，在他们的脑脊液中也检测到了SARS-CoV-2。本报告表明SARS-CoV-2具有神经侵袭潜力，提示该病毒能够从呼吸道传播至中枢神经系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5608/7920401/7388932a787e/13365_2020_938_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5608/7920401/7388932a787e/13365_2020_938_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5608/7920401/7388932a787e/13365_2020_938_Fig1_HTML.jpg

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