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伴有骨肉瘤分化的乳腺化生性癌：一例报告及文献复习

Breast Metaplastic Carcinoma With Osteosarcomatous Differentiation: A Case Report and literature Review.

作者信息

Yang Xue, Chen Ling, Shen Yan

机构信息

Department of Pathology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.

出版信息

Clin Pathol. 2022 Aug 25;15:2632010X221118056. doi: 10.1177/2632010X221118056. eCollection 2022 Jan-Dec.

DOI:10.1177/2632010X221118056
PMID:36051653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9425891/
Abstract

Metaplastic breast carcinoma (MBCs) is a rare heterogeneous group of malignancies. Herein, we report a case of metaplastic breast carcinoma, which had 2 components. One of them was typical invasive ductal carcinoma (IDC), the other one was presenting as osteosarcoma with lots of immature trabeculae. The results of immunohistochemistry showed different presentations between them. The majority of MBCs show triple-negativity for ER, PR, and HER-2 and are thus associated with poor prognosis. Our report shows that, it is necessary to describe the proportion of the components and the presentations of immunohistochemistry in the diagnosis, which will be important to develop specific and effective therapies.

摘要

化生性乳腺癌（MBCs）是一组罕见的异质性恶性肿瘤。在此，我们报告一例化生性乳腺癌病例，其具有两种成分。其中一种是典型的浸润性导管癌（IDC），另一种表现为带有大量未成熟小梁的骨肉瘤。免疫组化结果显示它们之间存在不同表现。大多数化生性乳腺癌对雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER-2）呈三阴性，因此预后较差。我们的报告表明，在诊断中描述各成分的比例及免疫组化表现很有必要，这对于制定特异性和有效的治疗方法至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/31bff7de38ab/10.1177_2632010X221118056-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/3aae0e427289/10.1177_2632010X221118056-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/2fb2779e285d/10.1177_2632010X221118056-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/1e4d12829f68/10.1177_2632010X221118056-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/b2d684906a6f/10.1177_2632010X221118056-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/31bff7de38ab/10.1177_2632010X221118056-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/3aae0e427289/10.1177_2632010X221118056-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/2fb2779e285d/10.1177_2632010X221118056-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/1e4d12829f68/10.1177_2632010X221118056-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/b2d684906a6f/10.1177_2632010X221118056-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/9425891/31bff7de38ab/10.1177_2632010X221118056-fig5.jpg

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