Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Ziaeian Hospital, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Int J Clin Pract. 2022 Aug 22;2022:1256408. doi: 10.1155/2022/1256408. eCollection 2022.
This randomized double-blind, placebo-controlled trial was conducted on 75 school-aged children with a diagnosis of ADHD based on DSM-V criteria. Children were randomly allocated to receive either vitamin D3 (2000 IU/day) or a placebo for 3 months. Serum IL-6, TNF- and 25(OH) D were assessed before and after the intervention to determine the effects of vitamin D on the highlighted parameters.
Serum levels of 25(OH) D increased significantly in the vitamin D group (=0.01). However, no significant differences in serum IL-6 and TNF- were found between both groups at the baseline and at the end of the intervention.
The findings revealed that vitamin D supplementation for 3 months is not efficacious in reducing inflammatory cytokines in children with ADHD. Further studies are required to confirm these results.
本随机双盲安慰剂对照试验纳入了 75 名符合 DSM-V 标准的 ADHD 学龄期儿童。儿童被随机分配接受维生素 D3（2000IU/天）或安慰剂治疗 3 个月。在干预前后评估血清白细胞介素 6（IL-6）、肿瘤坏死因子-α（TNF-α）和 25-羟维生素 D [25(OH) D]，以确定维生素 D 对这些指标的影响。
维生素 D 组的血清 25(OH) D 水平显著升高（P=0.01）。然而，在基线和干预结束时，两组间血清 IL-6 和 TNF-α均无显著差异。
研究结果表明，补充维生素 D 3 治疗 3 个月对 ADHD 儿童的炎症细胞因子没有疗效。需要进一步的研究来证实这些结果。
