Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.
CNS Neurol Disord Drug Targets. 2019;18(6):496-501. doi: 10.2174/1871527318666190703103709.
BACKGROUND & OBJECTIVE: Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood. The exact etiology of this disease is unknown, but it is believed to be related to the disorder of catecholaminergic and serotonergic systems. Also, serum vitamin D levels in patients with ADHD is lower. Several studies have also shown the effect of vitamin D on the synthesis pathways of dopamine, serotonin, and a number of neurotrophic factors. Therefore, this study aimed to investigate the effect of vitamin D3 supplementation on serum levels of Brain-Derived Neurotrophic Factor (BDNF), dopamine, and serotonin in school-aged children with ADHD.
Eighty-six children with ADHD were divided into two groups, based on randomized permuted blocks. Patients received 2000 IU vitamin D/day or a placebo for 12 weeks. Serum levels of BDNF, dopamine, serotonin, and 25-hydroxyvitamin D [25(OH)D] were measured at baseline and at the end of the study.
Serum levels of 25(OH)D and dopamine significantly increased in the vitamin D group, compared to the placebo group (p < 0.05). However, serum BDNF and serotonin levels did not change significantly.
Vitamin D3 supplementation in children with ADHD can increase serum dopamine levels, but further studies are needed to determine the effects of vitamin D on neurotrophic factors and serotonin.
注意力缺陷多动障碍（ADHD）是儿童期最常见的精神疾病之一。这种疾病的确切病因尚不清楚，但据信与儿茶酚胺能和 5-羟色胺能系统的紊乱有关。此外，ADHD 患者的血清维生素 D 水平较低。一些研究还表明维生素 D 对多巴胺、5-羟色胺和一些神经营养因子的合成途径有影响。因此，本研究旨在探讨维生素 D3 补充对学龄期 ADHD 儿童血清脑源性神经营养因子（BDNF）、多巴胺和 5-羟色胺水平的影响。
86 例 ADHD 患儿按随机区组法分为两组。患者接受 2000IU 维生素 D/天或安慰剂治疗 12 周。在基线和研究结束时测量血清 BDNF、多巴胺、5-羟色胺和 25-羟维生素 D [25（OH）D]水平。
与安慰剂组相比，维生素 D 组血清 25（OH）D 和多巴胺水平显著升高（p<0.05）。然而，血清 BDNF 和 5-羟色胺水平没有明显变化。
在 ADHD 儿童中补充维生素 D3 可以增加血清多巴胺水平，但需要进一步研究维生素 D 对神经营养因子和 5-羟色胺的影响。
