接种 ChAdOx1 nCoV-19 疫苗后出现的疫苗相关 GABA-B 受体抗体脑炎。
Postvaccinal GABA-B receptor antibody encephalitis after ChAdOx1 nCoV-19 vaccination.
机构信息
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Hospital Medicine Center, Seoul National University Hospital, Seoul, South Korea.
出版信息
Ann Clin Transl Neurol. 2022 Oct;9(10):1673-1678. doi: 10.1002/acn3.51659. Epub 2022 Sep 2.
Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV-19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic-clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV-19 vaccine. Clinical presentation and magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) test results were compatible with limbic encephalitis. Synaptic autoantibody tests confirmed serum and CSF GABA B receptor antibodies were present. The patient was treated with immunotherapy with intravenous immunoglobulin and rituximab. This GABA-B receptor antibody encephalitis case occurred presumably due to transient autoantibody production following vaccine administration.
几例腺病毒载体新冠疫苗（ChAdOx1 nCoV-19，阿斯利康）接种后出现自身免疫性脑炎。我们遇到一位男性患者，在接种第二剂 ChAdOx1 nCoV-19 疫苗后突然出现全身强直阵挛发作、认知功能下降和步态障碍。临床表现、磁共振成像（MRI）和脑脊液（CSF）检查结果符合边缘性脑炎。突触自身抗体检测证实血清和 CSF 中 GABA B 受体抗体阳性。患者接受了静脉注射免疫球蛋白和利妥昔单抗的免疫治疗。这种 GABA-B 受体抗体脑炎可能是由于疫苗接种后短暂的自身抗体产生。
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