Chen Yun, Petzold Max, Rüetschi Ulrika, Dahlstrand Johan, Löfstedt Petra, Corell Maria, Friberg Peter
School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Clinial Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Psychoneuroendocrinology. 2022 Dec;146:105908. doi: 10.1016/j.psyneuen.2022.105908. Epub 2022 Aug 27.
While hair cortisol is proposed as a biomarker for chronic stress and a possible mediator linking chronic stress and cardiovascular risk in adults, studies in adolescents are scarce. We explored the associations between self-perceived stress, hair cortisol (HairF) and cortisone (HairE), and cardiometabolic risk markers in adolescents. Further, we examined whether association between self-perceived stress and HairF may depend on the use of the coping strategies "shift-persist".
Participants were 7th grade pupils recruited to the STudy of Adolescence Resilience and Stress (STARS) and data from the baseline examinations were used. Adolescents (n = 1553, 26 % boys, M=13.6, SD = 0.4) completed questionnaires assessing perceived stress and coping strategies "shift-persist", provided hair sample, and examined for cardiometabolic risk factors including waist circumference (WC), body mass index (BMI) z-score, blood pressure, and white blood cell counts (WBC). HairF and HairE were analysed using liquid chromatography with tandem mass spectrometry. We conducted descriptive analyses (Student's t-test, Wilcoxon Signed Ranks test, Chi-square test) and linear regression analyses.
Perceived stress was not associated with HairF, neither had the use of coping strategies "shift-persist" any influence on this association. Both HairF and HairE were positively associated with BMI z-score (beta coefficients (β): 0.178 (p < 0.001) and 0.119 (p < 0.001) for boys; 0.123 (p < 0.001) and 0.089 (p < 0.01) for girls) and WC (β: 0.089 (p > 0.05) and 0.098 (p < 0.05) for boys; 0.103 (p < 0.01) and 0.076 (p < 0.05) for girls). Perceived stress was also positively associated with BMI z-score and WC. Perceived stress, but not HairF, remained associated with WC in boys (β = 0.200, p < 0.001) in the models with HairF and perceived stress presented simultaneously. Modest association between HairE and WBC was found in boys (β = 0.149, p < 0.01).
The study supports the association between chronic stress and overweight/obesity in adolescents. Hair cortisol and self-perceived stress capture different aspects of how chronic stress is related to overweight/obesity in adolescents.
虽然头发皮质醇被提议作为慢性应激的生物标志物，并且可能是连接成人慢性应激和心血管风险的中介物，但针对青少年的研究却很匮乏。我们探讨了青少年自我感知的压力、头发皮质醇（HairF）和可的松（HairE）与心脏代谢风险标志物之间的关联。此外，我们还研究了自我感知的压力与HairF之间的关联是否可能取决于应对策略“转换 - 坚持”的使用情况。
参与者为招募自青少年复原力与压力研究（STARS）的七年级学生，并使用了基线检查的数据。青少年（n = 1553，26%为男孩，平均年龄M = 13.6岁，标准差SD = 0.4）完成了评估感知压力和应对策略“转换 - 坚持”的问卷，提供了头发样本，并接受了心脏代谢风险因素检查，包括腰围（WC）、体重指数（BMI）z评分、血压和白细胞计数（WBC）。使用液相色谱 - 串联质谱法分析HairF和HairE。我们进行了描述性分析（学生t检验、Wilcoxon符号秩检验、卡方检验）和线性回归分析。
感知压力与HairF无关，应对策略“转换 - 坚持”的使用对这种关联也没有任何影响。HairF和HairE均与BMI z评分呈正相关（男孩的β系数（β）：0.178（p < 0.001）和0.119（p < 0.001）；女孩的β系数：0.123（p < 0.001）和0.089（p < 0.01））以及与WC呈正相关（男孩的β系数：0.089（p > 0.05）和0.098（p < 0.05）；女孩的β系数：0.103（p < 0.01）和0.076（p < 0.05））。感知压力也与BMI z评分和WC呈正相关。在同时呈现HairF和感知压力的模型中，男孩的感知压力而非HairF与WC仍存在关联（β = 0.200，p < 0.001）。在男孩中发现HairE与WBC之间存在适度关联（β = 0.149，p < 0.01）。
该研究支持青少年慢性应激与超重/肥胖之间的关联。头发皮质醇和自我感知的压力反映了慢性应激与青少年超重/肥胖之间关系的不同方面。
