Department of Microbiology, University of Medicine 1, No. 245, Myoma Kyaung Street, Lanmadaw Township, Yangon, Myanmar; Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Parasitol Int. 2023 Feb;92:102663. doi: 10.1016/j.parint.2022.102663. Epub 2022 Sep 1.
Strongyloides is a genus of parasitic nematodes of vertebrates comprising approximately 50 documented species, each with various host ranges. Among these, three species (S. stercoralis, S. fuelleborni, and S. cebus) are known to infect primate hosts. S. fuelleborni typically infects non-human primates in the Old World. To complement the existing information on the global genetic structure of this species, we conducted a genotyping study of S. fuelleborni samples collected from rhesus macaques in Myanmar, Japanese macaques in Japan, and some zoo-kept primates. This study identified a novel haplotype group in isolates from the Myanmar rhesus macaques. Subsequently, we obtained the complete or nearly complete mitochondrial genome sequences of S. fuelleborni, S. cebus (Strongyloides of New World monkeys), and S. vituli (Strongyloides of cattle). Phylogenetic analysis based on concatenated mitochondrial protein sequences of various Strongyloides species indicated a close relationship between S. fuelleborni, S. vituli and S. papillosus (Strongyloides in sheep and cattle). S. cebus is quite distantly related to both S. fuelleborni and S. stercoralis, which led to the hypothesis that the three primate Strongyloides species evolved independently as parasites of primates.
刚地弓形虫是一种寄生线虫的脊椎动物，包括大约 50 个有记载的物种，每个物种都有不同的宿主范围。其中，有三种（S. stercoralis、S. fuelleborni 和 S. cebus）已知感染灵长类宿主。S. fuelleborni 通常感染旧世界的非人类灵长类动物。为了补充该物种全球遗传结构的现有信息，我们对来自缅甸恒河猴、日本猕猴和一些动物园饲养的灵长类动物的 S. fuelleborni 样本进行了基因分型研究。这项研究在来自缅甸恒河猴的分离株中发现了一个新的单倍型群。随后，我们获得了 S. fuelleborni、S. cebus（新世界猴的刚地弓形虫）和 S. vituli（牛的刚地弓形虫）的完整或近乎完整的线粒体基因组序列。基于各种刚地弓形虫物种的线粒体蛋白序列的串联分析表明，S. fuelleborni、S. vituli 和 S. papillosus（绵羊和牛中的刚地弓形虫）之间存在密切关系。S. cebus 与 S. fuelleborni 和 S. stercoralis 关系非常疏远，这导致了三个灵长类刚地弓形虫物种作为灵长类寄生虫独立进化的假设。
