Afshan Kiran, Liu Yuchen, Viney Mark
Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Department of Evolution, Ecology and Behaviour, University of Liverpool, Liverpool, L69 7ZB, UK.
Parasit Vectors. 2024 Dec 20;17(1):527. doi: 10.1186/s13071-024-06626-6.
Strongyloides nematodes are livestock parasites, and Strongyloides papillosus infecting ruminant livestock can cause disease. Recent genomic analysis of several Strongyloides species is now facilitating population genomic analyses of natural Strongyloides infections, for example finding that Strongyloides ratti in wild UK rats exists as an assemblage of long-lived, asexual lineages.
Here we have initiated an investigation into the population genomics of S. papillosus in goats in Pakistan. We sampled Strongyloides from goat faeces and then whole genome sequenced individual larvae.
We find that S. papillosus is common, with a prevalence of 28%; that the population is genetically diverse and that individual goats commonly have mixed-genotype infections, and that there is evidence of admixture in only ca. 20% of worms.
These results now provoke further questions about the host range of different S. papillosus genotypes that can be investigated by further population genomic analyses in the future.
类圆线虫是家畜寄生虫，感染反刍家畜的乳头类圆线虫可引发疾病。近期对几种类圆线虫的基因组分析有助于对自然感染类圆线虫进行群体基因组分析，例如发现英国野生大鼠体内的鼠类圆线虫以长寿无性谱系组合的形式存在。
我们在此开展了对巴基斯坦山羊体内乳头类圆线虫群体基因组学的研究。我们从山羊粪便中采集类圆线虫样本，然后对单个幼虫进行全基因组测序。
我们发现乳头类圆线虫很常见，感染率为28%；该群体在基因上具有多样性，且个体山羊通常感染混合基因型，并且仅有约20%的虫体存在混合的证据。
这些结果引发了关于不同乳头类圆线虫基因型宿主范围的更多问题，未来可通过进一步的群体基因组分析进行研究。
