Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Mayo Clin Proc. 2022 Sep;97(9):1631-1640. doi: 10.1016/j.mayocp.2022.02.028.
To investigate the association between self-reported walking pace and type 2 diabetes (T2D) incidence and whether it differed by physical activity levels and walking time.
There were 162,155 participants (mean age, 57.1 years; 54.9% women) from the UK Biobank prospective study, recruited between 2006 and 2010, included in the study. Walking pace was self-reported and classified as brisk, average, or slow. Total physical activity and walking time were self-reported using the International Physical Activity Questionnaire. Association between walking pace and T2D incidence and the potential moderating role of physical activity and walking time were investigated using Cox proportional hazards models.
The median follow-up was 7.4 (interquartile range, 6.7 to 8.2) years. There were 4442 participants in whom T2D developed during the follow-up period. In the fully adjusted model (sociodemographic factors, diet, body mass index, and physical activity), average walking pace (hazard ratio [HR], 1.28; 95% CI, 1.14 to 1.44) and slow walking pace (HR, 1.91; 95% CI, 1.62 to 2.24) were associated with a higher T2D risk compared with brisk walking among women. Among men, average walking pace (HR, 1.28; 95% CI, 1.17 to 1.40) and slow walking pace (HR, 1.73; 95% CI, 1.50 to 1.99) were also associated with higher T2D risk. Compared with slow walkers, brisk walkers have the same diabetes incidence rate 18.6 and 16.0 years later, for women and men, respectively.
Average and slow walking pace was associated with a higher risk of incident T2D in both men and women, independent of major confounding factors. The associations were consistent across different physical activity levels and walking time.
探讨自我报告的行走速度与 2 型糖尿病（T2D）发病的关系，以及这种关系是否因体力活动水平和行走时间而异。
该研究纳入了来自英国生物库前瞻性研究的 162155 名参与者（平均年龄 57.1 岁，54.9%为女性），这些参与者于 2006 年至 2010 年期间入组。行走速度由自我报告，并分为快速、平均和缓慢。总体力活动和行走时间使用国际体力活动问卷进行自我报告。使用 Cox 比例风险模型探讨行走速度与 T2D 发病的关系，以及体力活动和行走时间的潜在调节作用。
中位随访时间为 7.4 年（四分位间距，6.7 至 8.2 年）。在随访期间，有 4442 名参与者发生了 T2D。在完全调整模型（社会人口因素、饮食、体重指数和体力活动）中，与快速行走相比，女性中平均行走速度（风险比 [HR]，1.28；95%置信区间 [CI]，1.14 至 1.44）和缓慢行走速度（HR，1.91；95%CI，1.62 至 2.24）与更高的 T2D 风险相关。在男性中，平均行走速度（HR，1.28；95%CI，1.17 至 1.40）和缓慢行走速度（HR，1.73；95%CI，1.50 至 1.99）也与更高的 T2D 风险相关。与慢走者相比，快走者的糖尿病发病率相同，女性和男性分别为 18.6 年和 16.0 年。
在男性和女性中，平均和缓慢的行走速度与 T2D 的发病风险增加相关，这与主要混杂因素无关。这种关联在不同的体力活动水平和行走时间内是一致的。
