Evangeliou Athanasios E, Spilioti Martha G, Vassilakou Despoina, Goutsaridou Fotini, Seyfried Thomas N
Fourth Department of Pediatrics, Division of Child Neurology and Metabolism, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
First Department of Neurology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Cureus. 2022 Aug 2;14(8):e27603. doi: 10.7759/cureus.27603. eCollection 2022 Aug.
A high-fat and low-carbohydrate diet was administered as a complementary and alternative therapy to a 54-year-old man suffering from non-small-cell lung cancer (NSCLC) with brain metastasis. Three months after the cessation of chemotherapy and radiotherapy, a ketogenic diet (KD) was initiated. This approach was an attempt to stabilize the disease progression after chemotherapy and radiotherapy. Computed tomography following radiation and chemotherapy showed a reduction in the right frontal lobe lesion from 5.5 cm × 6.2 cm to 4 cm × 2.7 cm, while the mass in the upper-right lung lobe reduced from 6.0 cm × 3.0 cm to 2.0 × 1.8 cm. Two years after KD initiation and without any other therapeutic intervention, the right frontal lobe lesion calcified and decreased in size to 1.9 cm × 1.0 cm, while the size of the lung mass further decreased to 1.7 cm × 1.0 cm. The size of the brain and lung lesion remained stable after nine years of KD therapy. However, dyslipidemia developed after this time which led to the discontinuation of the diet. No tumor relapse or health issues occurred for two years after the discontinuation of the diet. This case report indicates that the inclusion of ketogenic metabolic therapy following radiation and chemotherapy is associated with better clinical and survival outcomes for our patient with metastatic NSCLC.
对一名患有非小细胞肺癌（NSCLC）并伴有脑转移的54岁男性患者，采用高脂低碳水化合物饮食作为补充替代疗法。在停止化疗和放疗三个月后，开始采用生酮饮食（KD）。这种方法旨在稳定放化疗后的疾病进展。放化疗后的计算机断层扫描显示，右额叶病变从5.5厘米×6.2厘米缩小至4厘米×2.7厘米，右上肺叶肿块从6.0厘米×3.0厘米缩小至2.0×1.8厘米。开始生酮饮食两年后，在未进行任何其他治疗干预的情况下，右额叶病变钙化，大小缩小至1.9厘米×1.0厘米，肺部肿块大小进一步缩小至1.7厘米×1.0厘米。经过九年的生酮饮食治疗，脑和肺病变大小保持稳定。然而，此后出现了血脂异常，导致饮食中断。饮食中断后两年内未发生肿瘤复发或健康问题。本病例报告表明，对于我们这位转移性非小细胞肺癌患者，放化疗后采用生酮代谢疗法与更好的临床和生存结果相关。
