Seah Ivan, Ong Charles, Liu Zengping, Su Xinyi
Department of Ophthalmology, National University Hospital, Singapore, Singapore.
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Front Med (Lausanne). 2022 Aug 18;9:949543. doi: 10.3389/fmed.2022.949543. eCollection 2022.
Polymeric biomaterials are biological or synthetic substances which can be engineered to interact with biological systems for the diagnosis or treatment of diseases. These biomaterials have immense potential for treating eyes diseases, particularly the retina-a site of many inherited and acquired diseases. Polymeric biomaterials can be engineered to function both as an endotamponade agent and to prevent intraocular scarring in retinal detachment repair surgeries. They can also be designed as a drug delivery platform for treatment of retinal diseases. Finally, they can be used as scaffolds for cellular products and provide non-viral gene delivery solutions to the retina. This perspective article explains the role of polymeric biomaterials in the treatment of retinal conditions by highlighting recent advances being translated to clinical practice. The article will also identify potential hurdles to clinical translation as future research directions in the field.
聚合生物材料是可经设计与生物系统相互作用以用于疾病诊断或治疗的生物或合成物质。这些生物材料在治疗眼部疾病，尤其是视网膜疾病（许多遗传性和后天性疾病的发病部位）方面具有巨大潜力。聚合生物材料可经设计既作为内填充剂发挥作用，又在视网膜脱离修复手术中防止眼内瘢痕形成。它们还可被设计成用于治疗视网膜疾病的药物递送平台。最后，它们可用作细胞产品的支架，并为视网膜提供非病毒基因递送解决方案。这篇观点文章通过强调正在转化为临床实践的最新进展，阐述了聚合生物材料在治疗视网膜疾病中的作用。文章还将确定临床转化的潜在障碍，作为该领域未来的研究方向。
