PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer.

The upregulated proline rich 11 (PRR11) plays a critical role in cancer progression. The relevant biological functions of PRR11 in pan-cancer development are not well understood. In the current study, we found that was upregulated in 19 cancer types compared with that of normal tissues and high-expressed was a predictor of poor prognosis in 10 cancer types by bioinformatics. Then we showed that interfering PRR11 on three cancer cell lines could greatly inhibit cell proliferation and migration and arrest cells to S phase . Based on RNA-seq, downregulation of expression could extremely suppress the expression of and the cell cycle pathway identified by a differentially expressed gene analysis and an enrichment analysis. The expression of and was positively correlated in TCGA and independent GEO data sets. Importantly, we revealed that the PRR11 could express itself in the nucleus and interact with E2F1 on the promoter region to increase the expression of . Further results indicated that the expression of was also associated with poor prognosis in 10 cancer types, while downregulation of expression could inhibit cancer cell proliferation and migration. Therefore, we found that PRR11 served as an oncogene in pan-cancer and could influence the cell cycle progression through regulating the expression of by interacting with the transcription factor E2F1.