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The RAG key to vertebrate adaptive immunity descended directly from a bacterial ancestor.

作者信息

Tao Xin, Huang Ziwen, Chen Fan, Wang Xinli, Zheng Tingting, Yuan Shaochun, Xu Anlong

机构信息

State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Life Sciences, Sun Yat-sen University, China.

Center for Infection and Immunity, School of Medicine, Sun Yat-sen University, China.

出版信息

Natl Sci Rev. 2022 Apr 18;9(8):nwac073. doi: 10.1093/nsr/nwac073. eCollection 2022 Aug.

DOI:10.1093/nsr/nwac073
PMID:36060303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9435367/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4e3/9435367/0b62832faddd/nwac073fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4e3/9435367/0b62832faddd/nwac073fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4e3/9435367/0b62832faddd/nwac073fig1.jpg

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本文引用的文献

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Functional requirement of terminal inverted repeats for efficient activity reveals the early evolution of V(D)J recombination.末端反向重复序列高效活性的功能需求揭示了V(D)J重组的早期进化。
Natl Sci Rev. 2020 Feb;7(2):403-417. doi: 10.1093/nsr/nwz179. Epub 2019 Nov 13.
2
Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin.在原口动物中鉴定出类RAG转座子,表明它们起源于古老的两侧对称动物。
Mob DNA. 2020 May 6;11:17. doi: 10.1186/s13100-020-00214-y. eCollection 2020.
3
Structures of a RAG-like transposase during cut-and-paste transposition.
RAG 样转座酶在剪切粘贴转座过程中的结构。
Nature. 2019 Nov;575(7783):540-544. doi: 10.1038/s41586-019-1753-7. Epub 2019 Nov 13.
4
Transposon molecular domestication and the evolution of the RAG recombinase.转座子分子驯化与 RAG 重组酶的进化。
Nature. 2019 May;569(7754):79-84. doi: 10.1038/s41586-019-1093-7. Epub 2019 Apr 10.
5
The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.RAG转座子在整个后口动物进化过程中都具有活性,并在有颌脊椎动物中被驯化。
Immunogenetics. 2017 Jun;69(6):391-400. doi: 10.1007/s00251-017-0979-5. Epub 2017 Apr 28.
6
New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.重组激活基因蛋白和V(D)J重组进化起源的新见解。
FEBS J. 2017 Jun;284(11):1590-1605. doi: 10.1111/febs.13990. Epub 2017 Jan 6.
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Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.活性RAG转座子的发现揭示了V(D)J重组的起源。
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