Diep Darlene, Janitz Tyler, Kannan Kamilah S, Crane Alison, Aluri Bineetha, Wright Kevin, Baker William
Medicine, Burrell College of Osteopathic Medicine, Las Cruces, USA.
Biological Sciences, University of Georgia, Athens, USA.
Cureus. 2022 Jul 31;14(7):e27540. doi: 10.7759/cureus.27540. eCollection 2022 Jul.
Linear porokeratosis is a cutaneous disorder that typically presents in a unilateral linear formation. While the exact cause of linear porokeratosis is unknown, it is thought to be a downstream effect of disrupted cholesterol synthesis and mevalonate accumulation. Our patient is a 61-year-old male with an unusual case presentation of bilateral linear porokeratosis. He had failed numerous standard therapies. Pathologic examination of a skin biopsy was consistent with bilateral linear porokeratosis. Through a PubMed search, there have been limited reported cases of unilateral linear porokeratosis, but there have not been any reported cases of bilateral linear porokeratosis. There are currently limited therapies with satisfactory outcomes for variants of porokeratosis. While there are some studies on the topical application of cholesterol/lovastatin, limited studies have been performed on the linear form. Our study evaluates the efficacy of compounded topical cholesterol 2%/lovastatin 2% ointment on bilateral linear porokeratosis. The patient demonstrated a significant reduction of porokeratotic lesions on the treated arm compared to the untreated arm. Cholesterol/lovastatin is alternative therapy that can be considered in the treatment of linear porokeratosis and other porokeratosis variants.
线状汗孔角化症是一种皮肤疾病，通常呈单侧线状分布。虽然线状汗孔角化症的确切病因尚不清楚，但人们认为它是胆固醇合成中断和甲羟戊酸积累的下游效应。我们的患者是一名61岁男性，患有双侧线状汗孔角化症，病例表现不寻常。他尝试了多种标准治疗方法均告失败。皮肤活检的病理检查结果与双侧线状汗孔角化症相符。通过PubMed搜索发现，单侧线状汗孔角化症的报道病例有限，而双侧线状汗孔角化症尚无报道病例。目前，针对汗孔角化症的不同变体，疗效令人满意的治疗方法有限。虽然有一些关于局部应用胆固醇/洛伐他汀的研究，但针对线状形式的研究较少。我们的研究评估了复方2%胆固醇/2%洛伐他汀软膏对双侧线状汗孔角化症的疗效。与未治疗的手臂相比，患者治疗手臂上的汗孔角化性病变显著减少。胆固醇/洛伐他汀可作为一种替代疗法，用于治疗线状汗孔角化症和其他汗孔角化症变体。
