Biswas Asok
Department of Pathology, Alexander Donald Building, Western General Hospital, Edinburgh, United Kingdom.
Am J Dermatopathol. 2015 Feb;37(2):145-55. doi: 10.1097/DAD.0000000000000039.
Porokeratosis is a family of several disorders characterized histologically by the presence of cornoid lamellae. The presence of cornoid lamellae represents an abnormal form of keratinization, which unifies all types of porokeratosis. A significant variation in lesional morphology can result from peculiarities involving the cornoid lamellae and changes related to epidermal hyperplasia and dermal inflammation. This diversity has led to the recognition of several unusual clinicopathological variants of porokeratosis in recent years. Cornoid lamellation, however, is not pathognomonic of porokeratosis and can be seen in some inflammatory and inherited cutaneous disorders and also as an incidental finding. Some of these conditions can be confused with an atypical presentation of porokeratosis and vice versa. An awareness of the broad morphological spectrum of porokeratosis is crucial to avoid missing the diagnosis when appearances are far from typical. This issue is critical in patient management given the potential premalignant nature of porokeratosis.
汗孔角化症是一类疾病，其组织学特征为存在鸡眼样板层。鸡眼样板层的存在代表一种异常的角化形式，这是所有类型汗孔角化症的共同特征。皮损形态的显著差异可能源于鸡眼样板层的特殊情况以及与表皮增生和真皮炎症相关的变化。这种多样性导致近年来人们认识到汗孔角化症的几种不寻常的临床病理变异型。然而，鸡眼样板层并非汗孔角化症所特有，在一些炎症性和遗传性皮肤疾病中也可见到，甚至可能是偶然发现。其中一些情况可能与汗孔角化症的非典型表现相混淆，反之亦然。认识到汗孔角化症广泛的形态学谱对于避免在外观远非典型时漏诊至关重要。鉴于汗孔角化症潜在的恶变性质，这个问题在患者管理中至关重要。
