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一例罕见的非甾体抗炎药(NSAID)摄入继发的接吻性胃溃疡病例。

A Rare Case of Kissing Gastric Ulcers Secondary to Non-steroidal Anti-inflammatory Drug (NSAID) Intake.

作者信息

Vemulakonda Sri Hari Priya, Dutta Souradeep, Jain Ankit, Reddy Abhinaya, Nelamangala Ramakrishnaiah Vishnu Prasad

机构信息

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

出版信息

Cureus. 2022 Jul 30;14(7):e27490. doi: 10.7759/cureus.27490. eCollection 2022 Jul.

DOI:10.7759/cureus.27490
PMID:36060338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9423786/
Abstract

Peptic ulcer disease is a heterogeneous disease caused by the imbalance between mucosal protective and aggressive factors. Such ulcers are common in the anterior wall of the duodenum and gastric antrum. Kissing ulcers, although commonly reported in the duodenum, are rarely seen in the stomach. We present a rare case of an 85-year-old lady who had an index presentation of sudden onset hematemesis following ibuprofen intake. Endoscopy revealed kissing gastric ulcers, which are extremely rare secondary to non-steroidal anti-inflammatory drugs. She had complete healing after treatment with proton pump inhibitors.

摘要

消化性溃疡病是一种由黏膜保护因素和侵袭因素失衡引起的异质性疾病。此类溃疡常见于十二指肠前壁和胃窦。吻合性溃疡虽在十二指肠中常见报道,但在胃中很少见。我们报告一例罕见病例,一名85岁女性在服用布洛芬后首次出现突发呕血。内镜检查发现吻合性胃溃疡,这在非甾体抗炎药引起的情况中极为罕见。经质子泵抑制剂治疗后她完全愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9021/9423786/79524f077e01/cureus-0014-00000027490-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9021/9423786/dd7e6b6fc31c/cureus-0014-00000027490-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9021/9423786/79524f077e01/cureus-0014-00000027490-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9021/9423786/dd7e6b6fc31c/cureus-0014-00000027490-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9021/9423786/79524f077e01/cureus-0014-00000027490-i02.jpg

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Int J Surg Case Rep. 2025 Feb;127:110942. doi: 10.1016/j.ijscr.2025.110942. Epub 2025 Jan 24.
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Unusual Cause of Gastrointestinal Bleeding in an Elderly Adult: Gastric Kissing Ulcers.老年人胃肠道出血的不常见病因:胃亲吻性溃疡。
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本文引用的文献

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Coprescribing proton-pump inhibitors with nonsteroidal anti-inflammatory drugs: risks versus benefits.质子泵抑制剂与非甾体抗炎药联合处方:风险与益处
J Pain Res. 2018 Feb 14;11:361-374. doi: 10.2147/JPR.S156938. eCollection 2018.
2
KISSING GASTRIC ULCERS DUE TO BLUNT TRAUMA TO THE STOMACH.
Gastroenterol Nurs. 2016 Mar-Apr;39(2):131-3. doi: 10.1097/SGA.0000000000000218.
3
Kissing gastric ulcers causing acute pancreatitis and portal biliopathy: what's the link?导致急性胰腺炎和门静脉胆管病的吻状胃溃疡:其关联是什么?
JOP. 2013 Nov 10;14(6):646-8. doi: 10.6092/1590-8577/1546.
4
Endoscopic findings and associated risk factors in primary health care settings in Havana, Cuba.古巴哈瓦那基层医疗保健环境中的内镜检查结果及相关危险因素。
MEDICC Rev. 2012 Jan;14(1):30-7. doi: 10.37757/MR2012V14.N1.7.
5
Melaena as the presenting symptom of gastric mucosal injury due to blunt abdominal trauma.黑便作为钝性腹部创伤所致胃黏膜损伤的首发症状。
Emerg Med J. 2006 May;23(5):e34. doi: 10.1136/emj.2005.033621.
6
Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions.非甾体抗炎药与胃肠道损伤——问题与解决方案
Postgrad Med J. 2001 Feb;77(904):82-8. doi: 10.1136/pmj.77.904.82.