Hansen S H, Thomsen M
J Chromatogr. 1976 Jul 21;123(1):205-11. doi: 10.1016/s0021-9673(00)81116-4.
A high-performance liquid chromatographic method for the separation of individual components of polyene macrolide antibiotics has been developed. The three heptaene macrolide antibiotics, candicidin, levorin and trichomycin, have been investigated and compared. In all instances these compounds proved to be complex mixtures. It is demonstrated that candicidin and levorin are identical, whereas trichomycin differs in composition from these two substances.
已开发出一种用于分离多烯大环内酯类抗生素各组分的高效液相色谱法。对三种七烯大环内酯类抗生素杀假丝菌素、左菌素和曲古霉素进行了研究和比较。在所有情况下，这些化合物均被证明是复杂的混合物。结果表明，杀假丝菌素和左菌素是相同的，而曲古霉素在组成上与这两种物质不同。
