[Pharmacokinetics of benzylpenicillin and ampicillin in patients after combined administration with sulfalen and sulfadimethoxine].

Combined use of the penicillins and sulfanylamides in patients resulted in increased antibiotic blood levels and circulation. Retarded elimination of the penicillins was mainly due to the depositing effect of the sulfanylamides on the antibiotics at the account of increasing levels of the latter in peripheral tissues which was realized through increasing the drug distribution volume. It is not excluded that the primary mechanism of changing the penicillin kinetics in patients is lowered antibiotic binding to plasma proteins.