Bobrov V I, Olevskiĭ I Kh, Segel'man V S, Iakovlev V P
Antibiot Med Biotekhnol. 1987 May;32(5):385-8.
Combined use of the penicillins and sulfanylamides in patients resulted in increased antibiotic blood levels and circulation. Retarded elimination of the penicillins was mainly due to the depositing effect of the sulfanylamides on the antibiotics at the account of increasing levels of the latter in peripheral tissues which was realized through increasing the drug distribution volume. It is not excluded that the primary mechanism of changing the penicillin kinetics in patients is lowered antibiotic binding to plasma proteins.
在患者中联合使用青霉素和磺胺类药物会导致抗生素血液水平升高及循环增加。青霉素消除延迟主要是由于磺胺类药物对周围组织中抗生素的沉积作用，导致后者水平升高，进而使药物分布容积增加。不排除患者中青霉素动力学改变的主要机制是抗生素与血浆蛋白的结合降低。
