Bobrov V I, Beletskaia G T, Iakovlev V P
Antibiotiki. 1984 Nov;29(11):823-5.
The combined use of cephaloridin and cephalothin with sulfalen resulted in decreased binding of the cephalosporins by serum proteins and decreased rate of drug elimination in rabbits. It might be suggested that these two processes were interrelated. The decreased binding of the antibiotics by proteins in rabbits promoted an increase in the volume distribution of the drugs at the expense of a rise in the level of their penetration from the blood into the peripheral tissues.
头孢菌素I和头孢噻吩与磺胺甲噁唑联合使用导致兔血清蛋白对头孢菌素的结合减少，药物消除速率降低。可以认为这两个过程是相互关联的。兔体内蛋白质对抗生素结合的减少促使药物分布容积增加，代价是药物从血液渗透到外周组织的水平升高。
