Roy I, Bach V, Thadepalli H
Antimicrob Agents Chemother. 1977 Feb;11(2):258-61. doi: 10.1128/AAC.11.2.258.
A total of 334 clinical anaerobic isolates were tested in an anaerobic glove box by the agar dilution technique for susceptibility to clinically achievable levels of ticarcillin, carbenicillin, and penicillin. Thirty-two micrograms or less of penicillin per milliliter inhibited 91% of all strains, whereas 100 mug of carbenicillin and ticarcillin per ml inhibited 95 and 98%, respectively. A total of 82% (85 strains) of Bacteroides were inhibited by penicillin, and 93 and 96% were inhibited by carbenicillin and ticarcillin, respectively. Thirteen (24%) of 55 strains of Bacteroides fragilis tested were resistant to 32 mug of penicillin per ml, and 6 (11%) and 3 (5%) were resistant to 100 mug of carbenicillin and ticarcillin per ml, respectively. Within the therapeutic range, ticarcillin was the most effective of the three penicillins tested against B. fragilis subsp. fragilis.
采用琼脂稀释法，在厌氧手套箱中对总共334株临床厌氧菌分离株进行测试，以检测它们对临床可达到浓度的替卡西林、羧苄西林和青霉素的敏感性。每毫升32微克或更低浓度的青霉素可抑制所有菌株的91%，而每毫升100微克的羧苄西林和替卡西林分别可抑制95%和98%。总共82%（85株）的拟杆菌属菌株被青霉素抑制，分别有93%和96%被羧苄西林和替卡西林抑制。在测试的55株脆弱拟杆菌中，有13株（24%）对每毫升32微克的青霉素耐药，分别有6株（11%）和3株（5%）对每毫升100微克的羧苄西林和替卡西林耐药。在治疗范围内，替卡西林是所测试的三种青霉素中对脆弱拟杆菌脆弱亚种最有效的。
