人类甲状腺功能减退状态得到控制时庆大霉素和头孢唑林动力学的改变。
Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.
作者信息
Chanson P, Joly V, Contrepois A, Garaud J J, Bauchet J, Mohler J, Nguyen P C, Carbon C
出版信息
Antimicrob Agents Chemother. 1987 Apr;31(4):635-7. doi: 10.1128/AAC.31.4.635.
Abstract
We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.
摘要
我们研究了人类甲状腺功能减退状态的控制对单次静脉注射后头孢唑林和庆大霉素药代动力学参数的影响。选择这两种抗生素是因为它们与血清白蛋白的结合模式不同（庆大霉素为0%，头孢唑林为82%）。在甲状腺功能减退症中，仅头孢唑林的行为发生了改变，全身清除率降低，可能是由于尿排泄减少，分布容积减小，而头孢唑林与血清蛋白的结合没有明显改变。
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