Feely J, Stevenson I H, Crooks J
Clin Pharmacokinet. 1981 Jul-Aug;6(4):298-305. doi: 10.2165/00003088-198106040-00004.
The plasma protein binding of propranolol and warfarin was studied in vitro by ultrafiltration in hyper- and hypothyroid patients both before and after treatment. The degree of binding of propranolol was significantly decreased in hyperthyroid patients and increased in hypothyroid patients, and was negatively correlated with serum thyroxine and the free thyroxine index. The plasma protein binding of warfarin was also decreased in hyperthyroid patients, but was unchanged in hypothyroid patients. These results suggest that the binding of both acidic and basic drugs may be altered by thyroid disease.
通过超滤法在甲状腺功能亢进和减退患者治疗前后体外研究了普萘洛尔和华法林的血浆蛋白结合情况。甲状腺功能亢进患者中普萘洛尔的结合程度显著降低，甲状腺功能减退患者中则升高，且与血清甲状腺素和游离甲状腺素指数呈负相关。甲状腺功能亢进患者中华法林的血浆蛋白结合也降低，但甲状腺功能减退患者中无变化。这些结果表明，甲状腺疾病可能会改变酸性和碱性药物的结合情况。
