单剂量和多剂量金刚乙胺的药代动力学
Rimantadine pharmacokinetics after single and multiple doses.
作者信息
Wills R J, Farolino D A, Choma N, Keigher N
出版信息
Antimicrob Agents Chemother. 1987 May;31(5):826-8. doi: 10.1128/AAC.31.5.826.
Abstract
Twenty-four healthy adult male volunteers were randomly assigned to one of two rimantadine regimens. The 12 volunteers assigned to regimen 1 orally received a single 100-mg rimantadine tablet followed 5 days later by 100 mg of rimantadine twice a day for 10 days. Volunteers assigned to regimen 2 ingested a single 100-mg rimantadine tablet followed 5 days later by 100 mg once a day for 10 days. The results of the study suggest that the pharmacokinetics of rimantadine are linear and accumulation of the drug during repetitive multiple doses is predictable.
摘要
24名健康成年男性志愿者被随机分配到两种金刚烷胺治疗方案中的一种。分配到方案1的12名志愿者口服一片100毫克的金刚烷胺片，5天后，每天两次服用100毫克金刚烷胺，持续10天。分配到方案2的志愿者口服一片100毫克的金刚烷胺片，5天后，每天一次服用100毫克，持续10天。研究结果表明，金刚烷胺的药代动力学呈线性，多次重复给药时药物的蓄积是可预测的。
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本文引用的文献
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