单剂量金刚乙胺在青年人和儿童中的药代动力学。
Pharmacokinetics of a single dose of rimantadine in young adults and children.
作者信息
Anderson E L, Van Voris L P, Bartram J, Hoffman H E, Belshe R B
机构信息
Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701.
出版信息
Antimicrob Agents Chemother. 1987 Jul;31(7):1140-2. doi: 10.1128/AAC.31.7.1140.
Abstract
Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.
摘要
对儿童和年轻人给予单剂量的金刚乙胺，以评估这种抗病毒化合物的安全性和药代动力学。在年轻人中，金刚乙胺片剂的半衰期为27.7±4.9小时，糖浆制剂的半衰期为27.8±8.0小时。共有10名5至8岁的儿童接受了金刚乙胺糖浆制剂。金刚乙胺在儿童中的半衰期为24.8±9.4小时。单剂量的金刚乙胺在年轻人和儿童中耐受性良好。
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