Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.
Immune Cells and Antibody Engineering Research Center of Guizhou Province, Key Laboratory of Biology and Medical Engineering, School of Biology and Engineering, Guizhou Medical University, Guiyang, China.
Front Endocrinol (Lausanne). 2022 Aug 17;13:950326. doi: 10.3389/fendo.2022.950326. eCollection 2022.
Neuroblastoma breakpoint family, member 1 (), appears to be a double-edged sword with regard to its role in carcinogenesis. On the one hand, the tumor-suppressing functions of have been definitively observed in neuroblastoma, prostate cancer, cutaneous squamous cell carcinoma, and cervical cancer. On the other hand, there is evidence that regulates the colony formation, invasion, and maintenance of liver cancer cells and hence functions as an oncogene. The roles of are strictly dependent on the biological context and type of organization. However, a systematic pan-cancer analysis has thus far not been undertaken, and the significance of in the occurrence and progression of many malignancies is uncertain. In this paper, bioinformatics techniques were employed to analyze expression across different cancers and investigate the relationship between and clinical features, prognosis, genetic alteration, and tumor immune microenvironment, respectively. Our results show that is variably expressed in distinct tumor tissues and is also closely linked to clinical outcomes. In particular, compared to other tumor types, there was a strong negative correlation between expression and various components of the tumor microenvironment in adrenocortical carcinoma (ACC). We thus developed an -derived immune risk model based on -related immune genes; ACC patients with a high-risk score tended to have a poorer prognosis, accompanied by immune hyporesponsiveness. can be used as a prognostic biomarker for multiple cancers. Moreover, anti- immunotherapy may be suitable for treating ACC patients.
神经母细胞瘤断点家族成员 1() 在致癌作用方面似乎是一把双刃剑。一方面，在神经母细胞瘤、前列腺癌、皮肤鳞状细胞癌和宫颈癌中，已明确观察到的肿瘤抑制功能。另一方面，有证据表明调节肝癌细胞的集落形成、侵袭和维持，因此作为癌基因发挥作用。的作用严格依赖于生物学背景和组织类型。然而，迄今为止尚未进行系统的泛癌分析，在许多恶性肿瘤的发生和进展中意义尚不确定。在本文中，采用生物信息学技术分析了在不同癌症中的表达情况，并分别研究了与临床特征、预后、遗传改变和肿瘤免疫微环境之间的关系。我们的研究结果表明，在不同的肿瘤组织中表达不同，并且与临床结果密切相关。特别是与其他肿瘤类型相比，在肾上腺皮质癌(ACC)中，的表达与肿瘤微环境的各种成分之间存在强烈的负相关关系。因此，我们基于相关免疫基因开发了一个由衍生的免疫风险模型;评分较高的 ACC 患者预后较差，伴有免疫反应低下。可以作为多种癌症的预后生物标志物。此外，抗免疫疗法可能适合治疗 ACC 患者。
