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一名非HIV感染的肾移植患者中由巨细胞病毒引起的食管狭窄

Esophageal Stricture Caused by CMV in a Non-HIV-Infected Renal Transplant Patient.

作者信息

Tennant Tamera C, Pandey Samiksha, Edhi Ahmed I, Batke Mihaela

机构信息

Department of Internal Medicine Residency, William Beaumont Hospital, Royal Oak, MI.

Department of Gastroenterology, William Beaumont Hospital, Royal Oak, MI.

出版信息

ACG Case Rep J. 2022 Aug 31;9(8):e00836. doi: 10.14309/crj.0000000000000836. eCollection 2022 Aug.

Abstract

Esophageal stricture due to cytomegalovirus (CMV) infection is an uncommon pathology, with most reported cases occurring in patients infected with human immunodeficiency virus. We report a renal transplant patient who presented with progressive dysphagia and weight loss for 2 years. Endoscopic examination revealed a long esophageal stricture with a necrotic lesion but no typical CMV esophageal ulcers; immunostains were positive for CMV. Dysphagia resolved after treatment with ganciclovir and serial esophageal dilations. We are presenting the first case of esophageal stricture due to CMV esophagitis in a renal transplant patient without human immunodeficiency virus infection and are reviewing current literature.

摘要

巨细胞病毒(CMV)感染所致食管狭窄是一种罕见的病理情况,大多数报道病例发生在感染人类免疫缺陷病毒的患者中。我们报告一例肾移植患者,该患者出现进行性吞咽困难和体重减轻2年。内镜检查发现食管有长段狭窄并伴有坏死性病变,但未见典型的CMV食管溃疡;免疫染色CMV呈阳性。经更昔洛韦治疗及系列食管扩张术后吞咽困难缓解。我们报告了首例无人类免疫缺陷病毒感染的肾移植患者因CMV食管炎导致食管狭窄的病例,并对当前文献进行综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db0/9433075/de8a98bdee0e/ac9-9-e00836-g001.jpg

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