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新冠疫苗接种后发生面瘫的患者:是否加强接种?

Patients with post-COVID-19 vaccination facial palsy: To boost or not to boost?

作者信息

Cirillo Nicola, Orlandi Massimiliano, Colella Giuseppe

机构信息

Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, 3053 Victoria, Australia.

Department of Translational Medicine, Unit of Cardiology, Azienda Ospedaliero Universitaria University of Campania "Luigi Vanvitelli", Naples, Italy.

出版信息

Transl Neurosci. 2022 Aug 22;13(1):236-239. doi: 10.1515/tnsci-2022-0240. eCollection 2022 Jan 1.

DOI:10.1515/tnsci-2022-0240
PMID:36061346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9396751/
Abstract

A possible association between Bell's palsy and COVID-19 vaccination has been suggested. While it is likely that COVID-19 vaccine recipients from the general population do have a slightly increased risk of developing Bell's palsy, there are little data regarding this risk in individuals with a history of disease. Gaining a better understanding of this association is particularly important for informing evidence-based recommendations regarding future booster shots in subjects who developed Bell's palsy as a side effect of vaccination, or as a result of SARS-CoV-2 infection. We previously described the first case of COVID-19 vaccine-related Bell's palsy; here we report an 18-month clinical and electromyographic follow-up and discuss the implications of receiving further vaccine doses in patients with positive disease history.

摘要

有人提出贝尔氏面瘫与新冠疫苗接种之间可能存在关联。虽然普通人群中接种新冠疫苗的人患贝尔氏面瘫的风险可能略有增加,但关于有疾病史的个体的这种风险的数据很少。更好地了解这种关联对于为那些因接种疫苗副作用或感染SARS-CoV-2而患贝尔氏面瘫的受试者未来加强针的循证建议提供依据尤为重要。我们之前描述了首例与新冠疫苗相关的贝尔氏面瘫病例;在此,我们报告了18个月的临床和肌电图随访情况,并讨论了有阳性病史的患者接种更多疫苗剂量的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88ce/9396751/7547b472444b/j_tnsci-2022-0240-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88ce/9396751/7547b472444b/j_tnsci-2022-0240-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88ce/9396751/7547b472444b/j_tnsci-2022-0240-fig001.jpg

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本文引用的文献

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Neurological Events Reported after COVID-19 Vaccines: An Analysis of VAERS.新冠疫苗接种后报告的神经系统事件:疫苗不良事件报告系统(VAERS)分析
Ann Neurol. 2022 Mar 2;91(6):756-71. doi: 10.1002/ana.26339.
2
Do health-care workers need a COVID-19 vaccine booster?医护人员需要新冠病毒疫苗加强针吗?
Lancet Infect Dis. 2022 Jan;22(1):20. doi: 10.1016/S1473-3099(21)00782-9.
3
Association between vaccination with the BNT162b2 mRNA COVID-19 vaccine and Bell's palsy: a population-based study.BNT162b2 mRNA新冠疫苗接种与贝尔麻痹之间的关联:一项基于人群的研究。
Lancet Reg Health Eur. 2021 Dec;11:100236. doi: 10.1016/j.lanepe.2021.100236. Epub 2021 Nov 4.
4
Spectrum of neurological complications following COVID-19 vaccination.接种 COVID-19 疫苗后的神经系统并发症谱。
Neurol Sci. 2022 Jan;43(1):3-40. doi: 10.1007/s10072-021-05662-9. Epub 2021 Oct 31.
5
Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.新冠病毒疫苗接种后和 SARS-CoV-2 感染后的神经系统并发症。
Nat Med. 2021 Dec;27(12):2144-2153. doi: 10.1038/s41591-021-01556-7. Epub 2021 Oct 25.
6
Bell's palsy after inactivated COVID-19 vaccination in a patient with history of recurrent Bell's palsy: A case report.一名有复发性贝尔麻痹病史的患者在接种灭活新冠疫苗后发生贝尔麻痹:一例病例报告。
World J Clin Cases. 2021 Sep 26;9(27):8274-8279. doi: 10.12998/wjcc.v9.i27.8274.
7
Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting.BNT162b2 mRNA 新冠疫苗在全国范围内使用的安全性。
N Engl J Med. 2021 Sep 16;385(12):1078-1090. doi: 10.1056/NEJMoa2110475. Epub 2021 Aug 25.
8
The association between COVID-19 vaccination and Bell's palsy.新型冠状病毒肺炎疫苗接种与贝尔麻痹之间的关联。
Lancet Infect Dis. 2022 Jan;22(1):5-6. doi: 10.1016/S1473-3099(21)00467-9. Epub 2021 Aug 16.
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Bell's palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study.接种 mRNA(BNT162b2)和灭活(科兴)SARS-CoV-2 疫苗后出现贝尔麻痹:病例系列和巢式病例对照研究。
Lancet Infect Dis. 2022 Jan;22(1):64-72. doi: 10.1016/S1473-3099(21)00451-5. Epub 2021 Aug 16.
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JAMA Intern Med. 2021 Oct 1;181(10):1420. doi: 10.1001/jamainternmed.2021.4333.