Zhao Hanqiang, Xu Youguang, Wang Saisai, Li Pan, Wang Ting, Zhang Fang, Li Juan, Zhang Yapei, Ma Jinlong, Zhang Weifen
School of Pharmacy, Weifang Medical University, Weifang, Shandong, China.
Department of Pharmacy, Weifang Hospital of Traditional Chinese Medicine, Weifang, China.
Front Bioeng Biotechnol. 2022 Aug 19;10:943695. doi: 10.3389/fbioe.2022.943695. eCollection 2022.
Wound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making "Chinese Jianbing", a composite wound nano-dressing was developed consisting of a hydrophilic outer layer (chitosan&polyvinyl alcohol: CTS-PVA) and a hydrophobic inner layer (propolis&polycaprolactone: PRO-PCL) by combining casting and electrospinning methods for effective antibacterial and unidirectional removing excess biofluids. , the composite wound nano-dressing of PRO-PCL and CTS-PVA (PPCP) could strongly inhibit . Furthermore, PPCP wound dressing had excellent antioxidant properties and blood coagulation index for effective hemostatic. Importantly, it had a preferable water absorption for removing excess biofluid. , it had anti-inflammatory properties and promoted collagen Ⅰ preparation, which realized 80% wound healing on day 7. In short, the PPCP wound dressing provides a new direction and option for antibacterial and removes excess biofluid.
伤口感染和过多的渗出液会影响伤口愈合过程。然而，抗菌伤口敷料的缺点是生物流体无法有效清除。受制作“中国煎饼”的启发，通过结合流延法和静电纺丝法，开发了一种复合伤口纳米敷料，其由亲水性外层（壳聚糖和聚乙烯醇：CTS-PVA）和疏水性内层（蜂胶和聚己内酯：PRO-PCL）组成，用于有效抗菌和单向去除多余的生物流体。此外，PRO-PCL和CTS-PVA的复合伤口纳米敷料（PPCP）能强烈抑制……。此外，PPCP伤口敷料具有出色的抗氧化性能和凝血指数，可有效止血。重要的是，它具有较好的吸水性以去除多余的生物流体。此外，它具有抗炎特性并促进Ⅰ型胶原蛋白的生成，在第7天实现了80%的伤口愈合。简而言之，PPCP伤口敷料为抗菌和去除多余生物流体提供了新的方向和选择。
