Huang Qiu, He Fukun, Yu Jiafei, Zhang Jing, Du Xiangyun, Li Qing, Wang Gefei, Yu Ziyi, Chen Su
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu Key Laboratory of Fine Chemicals and Functional Polymer Materials, Nanjing Tech University, 30 Puzhu South Road, Nanjing 211816, P. R. China.
J Mater Chem B. 2021 Mar 21;9(11):2727-2735. doi: 10.1039/d0tb02305a. Epub 2021 Mar 8.
The preparation of dual-release pharmaceutical microfibers provides an ideal material for new biomedical applications. We describe a microfluidic spinning method for engineering heterotypic bead-on-string fibers with the ability to carry dual cargos and to deliver on demand. The core of our technology is to combine microfluidic spinning with biomaterial preparation, in which hydrophobic and hydrophilic cargos can be integrated into a bead-on-string microfiber structure. We demonstrate the loading of bovine serum albumin (BSA) in the sodium alginate phase and ibuprofen in the polylactic acid (PLA) phase, respectively. The heterotypic bead-on-string fibers are biocompatible and show hemostatic ability in vivo. These heterotypic bead-on-string fibers are then woven as a skin scaffold and shown to promote wound healing by loading antibacterial and anti-inflammatory cargos.
双释放药物微纤维的制备为新型生物医学应用提供了理想材料。我们描述了一种微流控纺丝方法，用于制造具有携带两种载荷并按需释放能力的异型串珠纤维。我们技术的核心是将微流控纺丝与生物材料制备相结合，其中疏水性和亲水性载荷可整合到串珠微纤维结构中。我们分别展示了在海藻酸钠相中负载牛血清白蛋白（BSA）以及在聚乳酸（PLA）相中负载布洛芬。这种异型串珠纤维具有生物相容性，并在体内显示出止血能力。然后将这些异型串珠纤维编织成皮肤支架，并通过负载抗菌和抗炎载荷显示出促进伤口愈合的作用。
