Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, PR China.
Laboratory of Biochemistry and Biomedical Materials, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, PR China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, PR China.
Carbohydr Polym. 2021 Jul 15;264:117965. doi: 10.1016/j.carbpol.2021.117965. Epub 2021 Mar 26.
Hemostasis is of great significance regardless of the smooth operation or postoperative recovery. Therefore, it is urgent to develop a hemostatic material with excellent biodegradability and biocompatibility. It is well known that both carboxymethyl chitosan and hyaluronic acid with biodegradability and biocompatibility have wound healing promoting property. Here, a degradable chitosan-based hydrogel was prepared based on carboxymethyl chitosan and cross-linked by oxidized hyaluronic acid. The hemostatic performance of the hydrogel in rat liver resection injury was evaluated which results showed that the hydrogel exhibited comparable hemostatic properties compared with Fibrin Sealant. In addition, the hydrogel proved to be rapidly absorbed by the body without significant accumulation in vivo, demonstrating good biodegradability and biocompatibility. The overall results suggested the hydrogel will be a promising hemostatic hydrogel for controlling bleeding.
止血对于手术的顺利进行和术后恢复都具有重要意义。因此，迫切需要开发一种具有优异生物降解性和生物相容性的止血材料。众所周知，具有生物降解性和生物相容性的羧甲基壳聚糖和透明质酸都具有促进伤口愈合的特性。在这里，基于羧甲基壳聚糖和氧化透明质酸交联制备了一种可降解的壳聚糖水凝胶。评估了水凝胶在大鼠肝切除损伤中的止血性能，结果表明，水凝胶的止血性能与纤维蛋白胶相当。此外，水凝胶被证明在体内能被迅速吸收，没有明显的体内蓄积，具有良好的生物降解性和生物相容性。总体结果表明，该水凝胶将是一种有前途的控制出血的止血水凝胶。
