Zhou Lian-Jiao, Wang Yu-Ying, Li Shu-Lan, Cao Ling, Jiang Feng-Lei, Maskow Thomas, Liu Yi
Department of Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
State Key Laboratory of Membrane Separation and Membrane Process & Tianjin Key Laboratory of Green Chemical Technology and Process Engineering, School of Chemistry, Tiangong University, Tianjin 300387, P. R. China.
ACS Omega. 2022 Aug 17;7(34):29984-29994. doi: 10.1021/acsomega.2c02986. eCollection 2022 Aug 30.
Cu-modified nanoparticles have been designed to mimic peroxidase, and their potent antibacterial and anti-biofilm abilities have been widely investigated. In this study, novel core-shell polydopamine (PDA)/Cu(OH)SO crystal (PDA/Cu) nanometer rods were prepared. The PDA/Cu nanometer rods show similar kinetic behaviors to chloride-activated peroxidases, exhibit excellent photothermal properties, and are sensitive to the concentrations of pH values and the substrate (i.e., HO). PDA/Cu nanometer rods could adhere to the bacteria and catalyze hydrogen peroxide (HO) to generate more reactive hydroxy radicals (OH) against and , Furthermore, PDA/Cu nanometer rods show enhanced catalytic and photothermal synergistic antibacterial activity. This work provides a simple, inexpensive, and effective strategy for antibacterial applications.
铜修饰的纳米颗粒已被设计用于模拟过氧化物酶，并且它们强大的抗菌和抗生物膜能力已得到广泛研究。在本研究中，制备了新型核壳聚多巴胺（PDA）/Cu(OH)SO晶体（PDA/Cu）纳米棒。PDA/Cu纳米棒表现出与氯离子激活的过氧化物酶相似的动力学行为，具有优异的光热性能，并且对pH值和底物（即HO）的浓度敏感。PDA/Cu纳米棒可以附着在细菌上并催化过氧化氢（HO）生成更多的活性羟基自由基（OH）来对抗和，此外，PDA/Cu纳米棒显示出增强的催化和光热协同抗菌活性。这项工作为抗菌应用提供了一种简单、廉价且有效的策略。
