Yagi H, Danno K, Maruguchi Y, Yamamoto M, Imamura S
Arch Dermatol. 1987 Jul;123(7):902-6.
The serum levels of squamous cell carcinoma (SCC)-related antigens (SCC-RAG) were assayed, utilizing the radioimmunoassay kit, in six patients with cutaneous SCC, two patients with Bowen's disease, 18 patients with other benign and malignant dermatoses, and six normal subjects. The SCC-RAG titers were significantly high in three patients with invasive SCC in whom primary tumors were either comparatively large or were associated with metastatic lesions, while they remained within the normal limit in patients with smaller-sized, nonmetastatic SCC, Bowen's disease, other non-SCC dermatoses, and in normal control subjects. The SCC-RAG titers, therefore, provided a useful tumor marker for cutaneous SCC, particularly in advanced stages. In such cases, the values were clearly correlated with tumor behaviors in response to or against treatments and with the development of metastasis.
利用放射免疫分析试剂盒检测了6例皮肤鳞状细胞癌患者、2例鲍温病患者、18例其他良恶性皮肤病患者及6例正常受试者血清中鳞状细胞癌（SCC）相关抗原（SCC-RAG）水平。3例浸润性SCC患者（其原发性肿瘤相对较大或伴有转移灶）的SCC-RAG滴度显著升高，而肿瘤较小、无转移的SCC患者、鲍温病患者、其他非SCC皮肤病患者及正常对照受试者的SCC-RAG滴度均在正常范围内。因此，SCC-RAG滴度为皮肤SCC提供了一种有用的肿瘤标志物，尤其是在晚期。在这些病例中，该指标值与肿瘤对治疗的反应或抵抗行为以及转移的发生明显相关。
