Frost F, Harter L, Milham S, Royce R, Smith A H, Hartley J, Enterline P
Arch Environ Health. 1987 May-Jun;42(3):148-52. doi: 10.1080/00039896.1987.9935813.
Lung cancer deaths occurring between 1935 and 1969 among women residing near an arsenic emitting smelter were examined. For three geographically defined exposure groups, the observed and expected number of lung cancer deaths were compared. In none of the exposure groups did the observed number of deaths exceed the expected. However, an index of exposure based on distance of residence from the smelter and duration of residence in the area was 27% higher for cases than for age-matched controls (p = .10). Adjusting for a latency of 20 yr, case exposures were 23% higher than for controls (p = .07). Dividing individuals into quintiles of exposure yielded odds ratios ranging from 1 to 1.6 (test of trend, p = .07).
对1935年至1969年间居住在一座砷排放冶炼厂附近的女性肺癌死亡情况进行了调查。针对三个按地理位置定义的暴露组，比较了肺癌死亡的观察数和预期数。在所有暴露组中，观察到的死亡数均未超过预期。然而，基于居住距离冶炼厂的远近以及在该地区居住时长的暴露指数，病例组比年龄匹配的对照组高27%（p = 0.10）。将潜伏期调整为20年，病例组的暴露比对照组高23%（p = 0.07）。将个体按暴露五分位数分组，得到的优势比范围为1至1.6（趋势检验，p = 0.07）。
